Cardiac ion channels and mechanisms for protection against atrial fibrillation.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

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Cardiac ion channels and mechanisms for protection against atrial fibrillation. / Grunnet, Morten; Bentzen, Bo Hjorth; Sørensen, Ulrik S; Diness, Jonas Goldin.

I: Reviews of Physiology, Biochemistry and Pharmacology, Bind 162, 2011, s. 1-58.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Grunnet, M, Bentzen, BH, Sørensen, US & Diness, JG 2011, 'Cardiac ion channels and mechanisms for protection against atrial fibrillation.', Reviews of Physiology, Biochemistry and Pharmacology, bind 162, s. 1-58.

APA

Grunnet, M., Bentzen, B. H., Sørensen, U. S., & Diness, J. G. (2011). Cardiac ion channels and mechanisms for protection against atrial fibrillation. Reviews of Physiology, Biochemistry and Pharmacology, 162, 1-58.

Vancouver

Grunnet M, Bentzen BH, Sørensen US, Diness JG. Cardiac ion channels and mechanisms for protection against atrial fibrillation. Reviews of Physiology, Biochemistry and Pharmacology. 2011;162:1-58.

Author

Grunnet, Morten ; Bentzen, Bo Hjorth ; Sørensen, Ulrik S ; Diness, Jonas Goldin. / Cardiac ion channels and mechanisms for protection against atrial fibrillation. I: Reviews of Physiology, Biochemistry and Pharmacology. 2011 ; Bind 162. s. 1-58.

Bibtex

@article{a4c316ce80c04856a16db913d881d5c4,
title = "Cardiac ion channels and mechanisms for protection against atrial fibrillation.",
abstract = "Atrial fibrillation (AF) is recognised as the most common sustained cardiac arrhythmia in clinical practice. Ongoing drug development is aiming at obtaining atrial specific effects in order to prevent pro-arrhythmic, devastating ventricular effects. In principle, this is possible due to a different ion channel composition in the atria and ventricles. The present text will review the aetiology of arrhythmias with focus on AF and include a description of cardiac ion channels. Channels that constitute potentially atria-selective targets will be described in details. Specific focus is addressed to the recent discovery that Ca(2+)-activated small conductance K(+) channels (SK channels) are important for the repolarisation of atrial action potentials. Finally, an overview of current pharmacological treatment of AF is included.",
author = "Morten Grunnet and Bentzen, {Bo Hjorth} and S{\o}rensen, {Ulrik S} and Diness, {Jonas Goldin}",
year = "2011",
language = "English",
volume = "162",
pages = "1--58",
journal = "Reviews of Physiology Biochemistry and Pharmacology",
issn = "0303-4240",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Cardiac ion channels and mechanisms for protection against atrial fibrillation.

AU - Grunnet, Morten

AU - Bentzen, Bo Hjorth

AU - Sørensen, Ulrik S

AU - Diness, Jonas Goldin

PY - 2011

Y1 - 2011

N2 - Atrial fibrillation (AF) is recognised as the most common sustained cardiac arrhythmia in clinical practice. Ongoing drug development is aiming at obtaining atrial specific effects in order to prevent pro-arrhythmic, devastating ventricular effects. In principle, this is possible due to a different ion channel composition in the atria and ventricles. The present text will review the aetiology of arrhythmias with focus on AF and include a description of cardiac ion channels. Channels that constitute potentially atria-selective targets will be described in details. Specific focus is addressed to the recent discovery that Ca(2+)-activated small conductance K(+) channels (SK channels) are important for the repolarisation of atrial action potentials. Finally, an overview of current pharmacological treatment of AF is included.

AB - Atrial fibrillation (AF) is recognised as the most common sustained cardiac arrhythmia in clinical practice. Ongoing drug development is aiming at obtaining atrial specific effects in order to prevent pro-arrhythmic, devastating ventricular effects. In principle, this is possible due to a different ion channel composition in the atria and ventricles. The present text will review the aetiology of arrhythmias with focus on AF and include a description of cardiac ion channels. Channels that constitute potentially atria-selective targets will be described in details. Specific focus is addressed to the recent discovery that Ca(2+)-activated small conductance K(+) channels (SK channels) are important for the repolarisation of atrial action potentials. Finally, an overview of current pharmacological treatment of AF is included.

M3 - Review

VL - 162

SP - 1

EP - 58

JO - Reviews of Physiology Biochemistry and Pharmacology

JF - Reviews of Physiology Biochemistry and Pharmacology

SN - 0303-4240

ER -

ID: 37726438