Candidate genes and pathways associated with gilles de la tourette syndrome—where are we?

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

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Candidate genes and pathways associated with gilles de la tourette syndrome—where are we? / Levy, Amanda M.; Paschou, Peristera; Tümer, Zeynep.

I: Genes, Bind 12, Nr. 9, 1321, 2021.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Levy, AM, Paschou, P & Tümer, Z 2021, 'Candidate genes and pathways associated with gilles de la tourette syndrome—where are we?', Genes, bind 12, nr. 9, 1321. https://doi.org/10.3390/genes12091321

APA

Levy, A. M., Paschou, P., & Tümer, Z. (2021). Candidate genes and pathways associated with gilles de la tourette syndrome—where are we? Genes, 12(9), [1321]. https://doi.org/10.3390/genes12091321

Vancouver

Levy AM, Paschou P, Tümer Z. Candidate genes and pathways associated with gilles de la tourette syndrome—where are we? Genes. 2021;12(9). 1321. https://doi.org/10.3390/genes12091321

Author

Levy, Amanda M. ; Paschou, Peristera ; Tümer, Zeynep. / Candidate genes and pathways associated with gilles de la tourette syndrome—where are we?. I: Genes. 2021 ; Bind 12, Nr. 9.

Bibtex

@article{7a3969732b6c43a0abab8c332a4eba9f,

title = "Candidate genes and pathways associated with gilles de la tourette syndrome—where are we?",

abstract = "Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental and-psychiatric tic-disorder of complex etiology which is often comorbid with obsessive-compulsive disorder (OCD) and/or attention deficit hyperactivity disorder (ADHD). Twin and family studies of GTS individuals have shown a high level of heritability suggesting, that genetic risk factors play an important role in disease etiology. However, the identification of major GTS susceptibility genes has been challenging, presumably due to the complex interplay between several genetic factors and environmental influences, low penetrance of each individual factor, genetic diversity in populations, and the presence of comorbid disorders. To understand the genetic components of GTS etiopathology, we conducted an extensive review of the literature, compiling the candidate susceptibility genes identified through various genetic approaches. Even though several strong candidate genes have hitherto been identified, none of these have turned out to be major susceptibility genes yet.",

keywords = "Cross-disorder, Diagnostics, Genetic association, Genome-wide association study, Gilles de la Tourette syndrome, GTS, Human genetics, Neurodevelopmental disorders, Neurotransmission, Tics",

author = "Levy, {Amanda M.} and Peristera Paschou and Zeynep T{\"u}mer",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/genes12091321",

language = "English",

volume = "12",

journal = "Genes",

issn = "2073-4425",

publisher = "M D P I AG",

number = "9",