Bone mineral density in adult patients treated with various antiepileptic drugs

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Standard

Bone mineral density in adult patients treated with various antiepileptic drugs. / Beniczky, Simona Alexandra; Viken, Janina; Jensen, Lars Thorbjørn; Andersen, Noémi Becser.

I: Seizure, Bind 21, Nr. 6, 07.2012, s. 471-2.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Beniczky, SA, Viken, J, Jensen, LT & Andersen, NB 2012, 'Bone mineral density in adult patients treated with various antiepileptic drugs', Seizure, bind 21, nr. 6, s. 471-2. https://doi.org/10.1016/j.seizure.2012.04.002

APA

Beniczky, S. A., Viken, J., Jensen, L. T., & Andersen, N. B. (2012). Bone mineral density in adult patients treated with various antiepileptic drugs. Seizure, 21(6), 471-2. https://doi.org/10.1016/j.seizure.2012.04.002

Vancouver

Beniczky SA, Viken J, Jensen LT, Andersen NB. Bone mineral density in adult patients treated with various antiepileptic drugs. Seizure. 2012 jul.;21(6):471-2. https://doi.org/10.1016/j.seizure.2012.04.002

Author

Beniczky, Simona Alexandra ; Viken, Janina ; Jensen, Lars Thorbjørn ; Andersen, Noémi Becser. / Bone mineral density in adult patients treated with various antiepileptic drugs. I: Seizure. 2012 ; Bind 21, Nr. 6. s. 471-2.

Bibtex

@article{4ca9dfecb514487d85474032c5d4135f,

title = "Bone mineral density in adult patients treated with various antiepileptic drugs",

abstract = "There is considerable evidence suggesting, that older antiepileptic drugs (AEDs) and some of the newer ones decrease bone mineral density (BMD). However, there is only limited and conflicting data concerning the effect of levetiracetam on BMD. In this cross-sectional study we analysed data from 168 adult consecutive outpatients treated with AEDs for more than 2 years, and who underwent measurement of the BMD. We compared the incidence of decreased BMD among the patients treated with 6 different AEDs: carbamazepine (CBZ), oxcarbazepine (OXC), valproic acid (VPA), lamotrigine (LTG), topiramate (TPM) and levetiracetam (LEV). Among the patients on monotherapy, reduced BMD was present significantly most often in patients treated with LEV and those treated with OXC. In the group of patients on polytherapy there was no significant difference in the incidence of low BMD among patients treated with various AEDs. Our data suggest that patients on long-term treatment with LEV have a higher risk for affection of bone density.",

keywords = "Absorptiometry, Photon, Adolescent, Adult, Aged, Anticonvulsants, Bone Density, Carbamazepine, Cross-Sectional Studies, Drug Therapy, Combination, Female, Fructose, Humans, Incidence, Male, Middle Aged, Piracetam, Triazines, Valproic Acid, Young Adult, Journal Article",

author = "Beniczky, {Simona Alexandra} and Janina Viken and Jensen, {Lars Thorbj{\o}rn} and Andersen, {No{\'e}mi Becser}",

year = "2012",

month = jul,

doi = "10.1016/j.seizure.2012.04.002",

language = "English",

volume = "21",

pages = "471--2",

journal = "Seizure : the journal of the British Epilepsy Association",

issn = "1059-1311",

publisher = "Elsevier",

number = "6",

}

RIS

TY - JOUR

T1 - Bone mineral density in adult patients treated with various antiepileptic drugs

AU - Beniczky, Simona Alexandra

AU - Viken, Janina

AU - Jensen, Lars Thorbjørn

AU - Andersen, Noémi Becser

PY - 2012/7

Y1 - 2012/7

N2 - There is considerable evidence suggesting, that older antiepileptic drugs (AEDs) and some of the newer ones decrease bone mineral density (BMD). However, there is only limited and conflicting data concerning the effect of levetiracetam on BMD. In this cross-sectional study we analysed data from 168 adult consecutive outpatients treated with AEDs for more than 2 years, and who underwent measurement of the BMD. We compared the incidence of decreased BMD among the patients treated with 6 different AEDs: carbamazepine (CBZ), oxcarbazepine (OXC), valproic acid (VPA), lamotrigine (LTG), topiramate (TPM) and levetiracetam (LEV). Among the patients on monotherapy, reduced BMD was present significantly most often in patients treated with LEV and those treated with OXC. In the group of patients on polytherapy there was no significant difference in the incidence of low BMD among patients treated with various AEDs. Our data suggest that patients on long-term treatment with LEV have a higher risk for affection of bone density.

AB - There is considerable evidence suggesting, that older antiepileptic drugs (AEDs) and some of the newer ones decrease bone mineral density (BMD). However, there is only limited and conflicting data concerning the effect of levetiracetam on BMD. In this cross-sectional study we analysed data from 168 adult consecutive outpatients treated with AEDs for more than 2 years, and who underwent measurement of the BMD. We compared the incidence of decreased BMD among the patients treated with 6 different AEDs: carbamazepine (CBZ), oxcarbazepine (OXC), valproic acid (VPA), lamotrigine (LTG), topiramate (TPM) and levetiracetam (LEV). Among the patients on monotherapy, reduced BMD was present significantly most often in patients treated with LEV and those treated with OXC. In the group of patients on polytherapy there was no significant difference in the incidence of low BMD among patients treated with various AEDs. Our data suggest that patients on long-term treatment with LEV have a higher risk for affection of bone density.

KW - Absorptiometry, Photon

KW - Adolescent

KW - Adult

KW - Aged

KW - Anticonvulsants

KW - Bone Density

KW - Carbamazepine

KW - Cross-Sectional Studies

KW - Drug Therapy, Combination

KW - Female

KW - Fructose

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Piracetam

KW - Triazines

KW - Valproic Acid

KW - Young Adult

KW - Journal Article

U2 - 10.1016/j.seizure.2012.04.002

DO - 10.1016/j.seizure.2012.04.002

M3 - Journal article

C2 - 22541979

VL - 21

SP - 471

EP - 472

JO - Seizure : the journal of the British Epilepsy Association

JF - Seizure : the journal of the British Epilepsy Association

SN - 1059-1311

IS - 6

ER -

ID: 168819213