Biofilm Survival Strategies in Chronic Wounds
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 1,3 MB, PDF-dokument
Bacterial biofilms residing in chronic wounds are thought to have numerous survival strate-gies, making them extremely difficult to eradicate and resulting in long-term infections. However, much of our knowledge regarding biofilm persistence stems from in vitro models and experiments performed in vivo in animal models. While the knowledge obtained from such experiments is highly valuable, its direct translation to the human clinical setting should be undertaken with caution. In this review, we highlight knowledge obtained from human clinical samples in different aspects of biofilm survival strategies. These strategies have been divided into segments of the following attributes: altered transcriptomic profiles, spatial distribution, the production of extracellular polymeric sub-stances, an altered microenvironment, inter-and intra-species interactions, and heterogeneity in the bacterial population. While all these attributes are speculated to contribute to the enhanced persistence of biofilms in chronic wounds, only some of them have been demonstrated to exist in human wounds. Some of the attributes have been observed in other clinical diseases while others have only been observed in vitro. Here, we have strived to clarify the limitations of the current knowledge in regard to this specific topic, without ignoring important in vitro and in vivo observations.
Originalsprog | Engelsk |
---|---|
Artikelnummer | 775 |
Tidsskrift | Microorganisms |
Vol/bind | 10 |
Udgave nummer | 4 |
ISSN | 2076-2607 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
Funding: This study was funded by the Novo Nordisk Foundation Challenge Program (NNF19OC0056411) to TB; Direktør Emil C. Hertz og Hustru Inger Hertz Foundation (KJR13016), Brødrene Hartmanns Foundation (A37411) and Aase og Ejnar Danielsens Foundation (21-10-0289) to THJ and ICT is funded by Magle Chemoswed, through a non-restricted research grant.
Funding Information:
This study was funded by the Novo Nordisk Foundation Challenge Program (NNF19OC0056411) to TB; Direkt?r Emil C. Hertz og Hustru Inger Hertz Foundation (KJR13016), Br?drene Hartmanns Foundation (A37411) and Aase og Ejnar Danielsens Foundation (21-10-0289) to THJ and ICT is funded by Magle Chemoswed, through a non-restricted research grant.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 305717240