TY - JOUR

T1 - Bile Acid Diarrhea in Microscopic Colitis

AU - Munck, Lars Kristian

AU - Wildt, Signe

AU - Borup, Christian

PY - 2024

Y1 - 2024

N2 - We read with great interest the study by Tome et al1 in which patients with microscopic colitis treated with bile acid sequestrants were identified in hospital registers and long-term efficacy assessed using retrospective data.Several aspects of the response to treatment in the 282 patients included were unusual. Only 64% had responded to previous treatment with budesonide, which is lower than the 81% clinical response rate reported in clinical trials2 and a large-volume case series.3 This discrepancy probably is owing to a selection bias favoring budesonide nonresponders, as would be expected from the current study's design.1 Ninety patients were tested for bile acid diarrhea, of whom 51 (57% of the tested and 18% of the total cohort) had a positive test.

AB - We read with great interest the study by Tome et al1 in which patients with microscopic colitis treated with bile acid sequestrants were identified in hospital registers and long-term efficacy assessed using retrospective data.Several aspects of the response to treatment in the 282 patients included were unusual. Only 64% had responded to previous treatment with budesonide, which is lower than the 81% clinical response rate reported in clinical trials2 and a large-volume case series.3 This discrepancy probably is owing to a selection bias favoring budesonide nonresponders, as would be expected from the current study's design.1 Ninety patients were tested for bile acid diarrhea, of whom 51 (57% of the tested and 18% of the total cohort) had a positive test.

U2 - 10.1016/j.cgh.2023.11.043

DO - 10.1016/j.cgh.2023.11.043

M3 - Letter

C2 - 38142834

AN - SCOPUS:85184758045

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

ER -