Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives

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Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives. / Bøgh, Helena Lykke; Stanislaus, Sharleny; Kjærstad, Hanne Lie; Sletved, Kimie Stefanie Ormstrup; Forman, Julie Lyng; Poulsen, Henrik Enghusen; Vinberg, Maj; Kessing, Lars Vedel; Coello, Klara.

I: Translational Psychiatry, Bind 12, Nr. 1, 2022, s. 327.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bøgh, HL, Stanislaus, S, Kjærstad, HL, Sletved, KSO, Forman, JL, Poulsen, HE, Vinberg, M, Kessing, LV & Coello, K 2022, 'Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives', Translational Psychiatry, bind 12, nr. 1, s. 327. https://doi.org/10.1038/s41398-022-02095-6

APA

Bøgh, H. L., Stanislaus, S., Kjærstad, H. L., Sletved, K. S. O., Forman, J. L., Poulsen, H. E., Vinberg, M., Kessing, L. V., & Coello, K. (2022). Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives. Translational Psychiatry, 12(1), 327. https://doi.org/10.1038/s41398-022-02095-6

Vancouver

Bøgh HL, Stanislaus S, Kjærstad HL, Sletved KSO, Forman JL, Poulsen HE o.a. Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives. Translational Psychiatry. 2022;12(1):327. https://doi.org/10.1038/s41398-022-02095-6

Author

Bøgh, Helena Lykke ; Stanislaus, Sharleny ; Kjærstad, Hanne Lie ; Sletved, Kimie Stefanie Ormstrup ; Forman, Julie Lyng ; Poulsen, Henrik Enghusen ; Vinberg, Maj ; Kessing, Lars Vedel ; Coello, Klara. / Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives. I: Translational Psychiatry. 2022 ; Bind 12, Nr. 1. s. 327.

Bibtex

@article{f340e2992ee64e48b579b7dc06491dc2,

title = "Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives",

abstract = "Enhanced oxidative stress-generated nucleoside damage may contribute to the increased cardiovascular disease mortality in patients with bipolar disorder (BD) but the association has never been investigated. We investigated the associations between oxidative stress-generated damage to DNA (8-oxodG) and RNA (8-oxoGuo), respectively, and three measures reflecting cardiovascular risk; namely, the Framingham 30-year risk score of cardiovascular diseases, the metabolic syndrome, and the insulin resistance index in 360 patients newly diagnosed with BD, 102 of their unaffected relatives (UR) and 197 healthy control individuals (HC). In sex- and age-adjusted models, the 30-year cardiovascular risk score increased by 20.8% (CI = 7.4-35.9%, p = 0.002) for every one nM/mM creatinine increase in 8-oxoGuo and by 15.6% (95% CI = 5.8-26.4%, p = 0.001) for every one nM/mM creatinine increase in 8-oxodG, respectively. Further, insulin resistance index increased by 24.1% (95% CI = 6.7-43%, p = 0.005) when 8-oxoGuo increased one nM/mM creatinine. The associations between cardiovascular measures and oxidative nucleoside damage were more pronounced in patients with BD compared with UR, and HC. Metabolic syndrome was not associated with nucleoside damage. Overall, higher oxidative stress-generated nucleoside damage was associated with a higher cardiovascular risk score and a higher degree of insulin resistance index, and having BD impacted the associations. Further, within patients, treatment with psychotropics seemed to enhance the associations between 30-year CVD risk score and insulin resistance index, respectively, and oxidatively stress-generated nucleoside damage. Our findings support enhanced oxidative stress-generated nucleoside damage as a putative pathophysiological mechanism that may mediate the higher cardiovascular risk observed in patients with BD already at the time of diagnosis.",

keywords = "8-Hydroxy-2'-Deoxyguanosine, Bipolar Disorder/genetics, Cardiovascular Diseases, Case-Control Studies, Creatinine, Heart Disease Risk Factors, Humans, Insulin Resistance, Nucleosides, Oxidative Stress/genetics, Risk Factors",

author = "B{\o}gh, {Helena Lykke} and Sharleny Stanislaus and Kj{\ae}rstad, {Hanne Lie} and Sletved, {Kimie Stefanie Ormstrup} and Forman, {Julie Lyng} and Poulsen, {Henrik Enghusen} and Maj Vinberg and Kessing, {Lars Vedel} and Klara Coello",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

doi = "10.1038/s41398-022-02095-6",

language = "English",

volume = "12",

pages = "327",

journal = "Translational Psychiatry",

issn = "2158-3188",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Associations between levels of oxidative nucleoside damage and cardiovascular risk in patients newly diagnosed with bipolar disorder and their unaffected relatives

AU - Bøgh, Helena Lykke

AU - Stanislaus, Sharleny

AU - Kjærstad, Hanne Lie

AU - Sletved, Kimie Stefanie Ormstrup

AU - Forman, Julie Lyng

AU - Poulsen, Henrik Enghusen

AU - Vinberg, Maj

AU - Kessing, Lars Vedel

AU - Coello, Klara

PY - 2022

Y1 - 2022

N2 - Enhanced oxidative stress-generated nucleoside damage may contribute to the increased cardiovascular disease mortality in patients with bipolar disorder (BD) but the association has never been investigated. We investigated the associations between oxidative stress-generated damage to DNA (8-oxodG) and RNA (8-oxoGuo), respectively, and three measures reflecting cardiovascular risk; namely, the Framingham 30-year risk score of cardiovascular diseases, the metabolic syndrome, and the insulin resistance index in 360 patients newly diagnosed with BD, 102 of their unaffected relatives (UR) and 197 healthy control individuals (HC). In sex- and age-adjusted models, the 30-year cardiovascular risk score increased by 20.8% (CI = 7.4-35.9%, p = 0.002) for every one nM/mM creatinine increase in 8-oxoGuo and by 15.6% (95% CI = 5.8-26.4%, p = 0.001) for every one nM/mM creatinine increase in 8-oxodG, respectively. Further, insulin resistance index increased by 24.1% (95% CI = 6.7-43%, p = 0.005) when 8-oxoGuo increased one nM/mM creatinine. The associations between cardiovascular measures and oxidative nucleoside damage were more pronounced in patients with BD compared with UR, and HC. Metabolic syndrome was not associated with nucleoside damage. Overall, higher oxidative stress-generated nucleoside damage was associated with a higher cardiovascular risk score and a higher degree of insulin resistance index, and having BD impacted the associations. Further, within patients, treatment with psychotropics seemed to enhance the associations between 30-year CVD risk score and insulin resistance index, respectively, and oxidatively stress-generated nucleoside damage. Our findings support enhanced oxidative stress-generated nucleoside damage as a putative pathophysiological mechanism that may mediate the higher cardiovascular risk observed in patients with BD already at the time of diagnosis.

AB - Enhanced oxidative stress-generated nucleoside damage may contribute to the increased cardiovascular disease mortality in patients with bipolar disorder (BD) but the association has never been investigated. We investigated the associations between oxidative stress-generated damage to DNA (8-oxodG) and RNA (8-oxoGuo), respectively, and three measures reflecting cardiovascular risk; namely, the Framingham 30-year risk score of cardiovascular diseases, the metabolic syndrome, and the insulin resistance index in 360 patients newly diagnosed with BD, 102 of their unaffected relatives (UR) and 197 healthy control individuals (HC). In sex- and age-adjusted models, the 30-year cardiovascular risk score increased by 20.8% (CI = 7.4-35.9%, p = 0.002) for every one nM/mM creatinine increase in 8-oxoGuo and by 15.6% (95% CI = 5.8-26.4%, p = 0.001) for every one nM/mM creatinine increase in 8-oxodG, respectively. Further, insulin resistance index increased by 24.1% (95% CI = 6.7-43%, p = 0.005) when 8-oxoGuo increased one nM/mM creatinine. The associations between cardiovascular measures and oxidative nucleoside damage were more pronounced in patients with BD compared with UR, and HC. Metabolic syndrome was not associated with nucleoside damage. Overall, higher oxidative stress-generated nucleoside damage was associated with a higher cardiovascular risk score and a higher degree of insulin resistance index, and having BD impacted the associations. Further, within patients, treatment with psychotropics seemed to enhance the associations between 30-year CVD risk score and insulin resistance index, respectively, and oxidatively stress-generated nucleoside damage. Our findings support enhanced oxidative stress-generated nucleoside damage as a putative pathophysiological mechanism that may mediate the higher cardiovascular risk observed in patients with BD already at the time of diagnosis.

KW - 8-Hydroxy-2'-Deoxyguanosine

KW - Bipolar Disorder/genetics

KW - Cardiovascular Diseases

KW - Case-Control Studies

KW - Creatinine

KW - Heart Disease Risk Factors

KW - Humans

KW - Insulin Resistance

KW - Nucleosides

KW - Oxidative Stress/genetics

KW - Risk Factors

U2 - 10.1038/s41398-022-02095-6

DO - 10.1038/s41398-022-02095-6

M3 - Journal article

C2 - 35948543

VL - 12

SP - 327

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

ER -

ID: 316417229