Association between vascular inflammation and inflammation in adipose tissue, spleen, and bone marrow in patients with psoriasis
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Association between vascular inflammation and inflammation in adipose tissue, spleen, and bone marrow in patients with psoriasis. / Kaiser, Hannah; Kvist-Hansen, Amanda; Krakauer, Martin; Gørtz, Peter Michael; Henningsen, Kristoffer Mads Aaris; Wang, Xing; Becker, Christine; Zachariae, Claus; Skov, Lone; Hansen, Peter Riis.
I: Life, Bind 11, Nr. 4, 305, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Association between vascular inflammation and inflammation in adipose tissue, spleen, and bone marrow in patients with psoriasis
AU - Kaiser, Hannah
AU - Kvist-Hansen, Amanda
AU - Krakauer, Martin
AU - Gørtz, Peter Michael
AU - Henningsen, Kristoffer Mads Aaris
AU - Wang, Xing
AU - Becker, Christine
AU - Zachariae, Claus
AU - Skov, Lone
AU - Hansen, Peter Riis
PY - 2021
Y1 - 2021
N2 - Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.
AB - Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.
KW - F-FDG-PET/CT
KW - Adipose tissue
KW - Cardiovascular disease
KW - Psoriasis
KW - Vascular inflammation
U2 - 10.3390/life11040305
DO - 10.3390/life11040305
M3 - Journal article
C2 - 33915972
AN - SCOPUS:85104063153
VL - 11
JO - Life
JF - Life
SN - 2075-1729
IS - 4
M1 - 305
ER -
ID: 260594105