Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Thymic stromal-derived lymphopoietin (TSLP) and interleukin-7 share a common receptor chain, IL-7Ralpha. IL-7 is involved in T-cell homeostasis, and TSLP induces production of pro-allergic cytokines. The gene encoding the IL-7Ralpha chain is polymorphic, and investigation of inhalation allergic patients compared with controls showed significant association with two alleles at position +1237 and +2087.
Originalsprog | Engelsk |
---|---|
Tidsskrift | International Journal of Immunogenetics (Print Edition) |
Vol/bind | 34 |
Udgave nummer | 3 |
Sider (fra-til) | 149-51 |
Antal sider | 3 |
ISSN | 1744-3121 |
DOI | |
Status | Udgivet - 2007 |
ID: 43535286