Association and genetic overlap between clinical chemistry tests and migraine

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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Association and genetic overlap between clinical chemistry tests and migraine. / Tanha, Hamzeh M.; The International Headache Genetics Consortium (IHGC).

I: Cephalalgia, Bind 41, Nr. 11-12, 2021, s. 1208-1221.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tanha, HM & The International Headache Genetics Consortium (IHGC) 2021, 'Association and genetic overlap between clinical chemistry tests and migraine', Cephalalgia, bind 41, nr. 11-12, s. 1208-1221. https://doi.org/10.1177/03331024211018131

APA

Tanha, H. M., & The International Headache Genetics Consortium (IHGC) (2021). Association and genetic overlap between clinical chemistry tests and migraine. Cephalalgia, 41(11-12), 1208-1221. https://doi.org/10.1177/03331024211018131

Vancouver

Tanha HM, The International Headache Genetics Consortium (IHGC). Association and genetic overlap between clinical chemistry tests and migraine. Cephalalgia. 2021;41(11-12):1208-1221. https://doi.org/10.1177/03331024211018131

Author

Tanha, Hamzeh M. ; The International Headache Genetics Consortium (IHGC). / Association and genetic overlap between clinical chemistry tests and migraine. I: Cephalalgia. 2021 ; Bind 41, Nr. 11-12. s. 1208-1221.

Bibtex

@article{a21cfcce3a4c4e4aac231a8f16eedca6,

title = "Association and genetic overlap between clinical chemistry tests and migraine",

abstract = "Introduction: In this paper, we studied several serum clinical chemistry tests of cardiovascular disease (CVD), iron deficiency anemia, liver and kidney disorders in migraine. Methods: We first explored the association of 22 clinical chemistry tests with migraine risk in 697 migraine patients and 2722 controls. To validate and interpret association findings, cross-trait genetic analyses were conducted utilising genome-wide association study (GWAS) data comprising 23,986 to 452,264 individuals. Results: Significant associations with migraine risk were identified for biomarkers of CVD risk, iron deficiency and liver dysfunction (odds ratios = 0.86–1.21; 1 × 10−4 < p < 3 × 10−2). Results from cross-trait genetic analyses corroborate the significant biomarker associations and indicate their relationship with migraine is more consistent with biological pleiotropy than causality. For example, association and genetic overlap between a lower level of HDL-C and increased migraine risk are due to shared biology rather than a causal relationship. Furthermore, additional genetic analyses revealed shared genetics among migraine, the clinical chemistry tests, and heart problems and iron deficiency anemia, but not liver disease. Conclusions: These findings highlight common biological mechanisms underlying migraine, heart problems and iron deficiency anemia and provide support for their investigation in the development of novel therapeutic and dietary interventions.",

keywords = "Biochemistry tests, gene-based genetic overlap, genetic correlation, Mendelian randomisation, SNP-based genetic overlap",

author = "Tanha, {Hamzeh M.} and Martin, {Nicholas G.} and Whitfield, {John B.} and Nyholt, {Dale R.} and Padhraig Gormley and Verneri Anttila and Winsvold, {Bendik S.} and Priit Palta and Tonu Esko and Pers, {Tune H.} and Farh, {Kai How} and Ester Cuenca-Leon and Mikko Muona and Furlotte, {Nicholas A.} and Tobias Kurth and Andres Ingason and George McMahon and Lannie Ligthart and Terwindt, {Gisela M.} and Mikko Kallela and Freilinger, {Tobias M.} and Caroline Ran and Gordon, {Scott G.} and Stam, {Anine H.} and Stacy Steinberg and Guntram Borck and Markku Koiranen and Lydia Quaye and Adams, {Hieab H.H.} and Terho Lehtim€aki and Sarin, {Antti Pekka} and Juho Wedenoja and Hinds, {David A.} and Buring, {Julie E.} and Markus Schurks and Ridker, {Paul M.} and Hrafnsdottir, {Maria Gudlaug} and Hreinn Stefansson and Ring, {Susan M.} and Hottenga, {Jouke Jan} and Penninx, {Brenda WJH} and Markus F€arkkil€a and Ville Artto and Mari Kaunisto and Salli Veps€al€ainen and Rainer Malik and Christensen, {Anne Francke} and Hansen, {Thomas Folkmann} and Thomas Werge and Jes Olesen and {The International Headache Genetics Consortium (IHGC)}",

note = "Publisher Copyright: {\textcopyright} International Headache Society 2021.",

year = "2021",

doi = "10.1177/03331024211018131",

language = "English",

volume = "41",

pages = "1208--1221",

journal = "Cephalalgia",

issn = "0800-1952",

publisher = "SAGE Publications",

number = "11-12",

}

RIS

TY - JOUR

T1 - Association and genetic overlap between clinical chemistry tests and migraine

AU - Tanha, Hamzeh M.

AU - Martin, Nicholas G.

AU - Whitfield, John B.

AU - Nyholt, Dale R.

AU - Gormley, Padhraig

AU - Anttila, Verneri

AU - Winsvold, Bendik S.

AU - Palta, Priit

AU - Esko, Tonu

AU - Pers, Tune H.

AU - Farh, Kai How

AU - Cuenca-Leon, Ester

AU - Muona, Mikko

AU - Furlotte, Nicholas A.

AU - Kurth, Tobias

AU - Ingason, Andres

AU - McMahon, George

AU - Ligthart, Lannie

AU - Terwindt, Gisela M.

AU - Kallela, Mikko

AU - Freilinger, Tobias M.

AU - Ran, Caroline

AU - Gordon, Scott G.

AU - Stam, Anine H.

AU - Steinberg, Stacy

AU - Borck, Guntram

AU - Koiranen, Markku

AU - Quaye, Lydia

AU - Adams, Hieab H.H.

AU - Lehtim€aki, Terho

AU - Sarin, Antti Pekka

AU - Wedenoja, Juho

AU - Hinds, David A.

AU - Buring, Julie E.

AU - Schurks, Markus

AU - Ridker, Paul M.

AU - Hrafnsdottir, Maria Gudlaug

AU - Stefansson, Hreinn

AU - Ring, Susan M.

AU - Hottenga, Jouke Jan

AU - Penninx, Brenda WJH

AU - F€arkkil€a, Markus

AU - Artto, Ville

AU - Kaunisto, Mari

AU - Veps€al€ainen, Salli

AU - Malik, Rainer

AU - Christensen, Anne Francke

AU - Hansen, Thomas Folkmann

AU - Werge, Thomas

AU - Olesen, Jes

AU - The International Headache Genetics Consortium (IHGC)

PY - 2021

Y1 - 2021

N2 - Introduction: In this paper, we studied several serum clinical chemistry tests of cardiovascular disease (CVD), iron deficiency anemia, liver and kidney disorders in migraine. Methods: We first explored the association of 22 clinical chemistry tests with migraine risk in 697 migraine patients and 2722 controls. To validate and interpret association findings, cross-trait genetic analyses were conducted utilising genome-wide association study (GWAS) data comprising 23,986 to 452,264 individuals. Results: Significant associations with migraine risk were identified for biomarkers of CVD risk, iron deficiency and liver dysfunction (odds ratios = 0.86–1.21; 1 × 10−4 < p < 3 × 10−2). Results from cross-trait genetic analyses corroborate the significant biomarker associations and indicate their relationship with migraine is more consistent with biological pleiotropy than causality. For example, association and genetic overlap between a lower level of HDL-C and increased migraine risk are due to shared biology rather than a causal relationship. Furthermore, additional genetic analyses revealed shared genetics among migraine, the clinical chemistry tests, and heart problems and iron deficiency anemia, but not liver disease. Conclusions: These findings highlight common biological mechanisms underlying migraine, heart problems and iron deficiency anemia and provide support for their investigation in the development of novel therapeutic and dietary interventions.

AB - Introduction: In this paper, we studied several serum clinical chemistry tests of cardiovascular disease (CVD), iron deficiency anemia, liver and kidney disorders in migraine. Methods: We first explored the association of 22 clinical chemistry tests with migraine risk in 697 migraine patients and 2722 controls. To validate and interpret association findings, cross-trait genetic analyses were conducted utilising genome-wide association study (GWAS) data comprising 23,986 to 452,264 individuals. Results: Significant associations with migraine risk were identified for biomarkers of CVD risk, iron deficiency and liver dysfunction (odds ratios = 0.86–1.21; 1 × 10−4 < p < 3 × 10−2). Results from cross-trait genetic analyses corroborate the significant biomarker associations and indicate their relationship with migraine is more consistent with biological pleiotropy than causality. For example, association and genetic overlap between a lower level of HDL-C and increased migraine risk are due to shared biology rather than a causal relationship. Furthermore, additional genetic analyses revealed shared genetics among migraine, the clinical chemistry tests, and heart problems and iron deficiency anemia, but not liver disease. Conclusions: These findings highlight common biological mechanisms underlying migraine, heart problems and iron deficiency anemia and provide support for their investigation in the development of novel therapeutic and dietary interventions.

KW - Biochemistry tests

KW - gene-based genetic overlap

KW - genetic correlation

KW - Mendelian randomisation

KW - SNP-based genetic overlap

U2 - 10.1177/03331024211018131

DO - 10.1177/03331024211018131

M3 - Journal article

C2 - 34130515

AN - SCOPUS:85117387254

VL - 41

SP - 1208

EP - 1221

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 11-12

ER -

ID: 283003305