Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy: A Randomized Trial of Photoaged Skin

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Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy : A Randomized Trial of Photoaged Skin. / Mogensen, Mette; Hendel, Kristoffer; Ung, Vilde; Wenande, Emily; Togsverd-Bo, Katrine; Forman, Julie L.; Haedersdal, Merete.

I: Dermatology, Bind 238, 2022, s. 422–429.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Mogensen, M, Hendel, K, Ung, V, Wenande, E, Togsverd-Bo, K, Forman, JL & Haedersdal, M 2022, 'Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy: A Randomized Trial of Photoaged Skin', Dermatology, bind 238, s. 422–429. https://doi.org/10.1159/000517960

APA

Mogensen, M., Hendel, K., Ung, V., Wenande, E., Togsverd-Bo, K., Forman, J. L., & Haedersdal, M. (2022). Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy: A Randomized Trial of Photoaged Skin. Dermatology, 238, 422–429. https://doi.org/10.1159/000517960

Vancouver

Mogensen M, Hendel K, Ung V, Wenande E, Togsverd-Bo K, Forman JL o.a. Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy: A Randomized Trial of Photoaged Skin. Dermatology. 2022;238:422–429. https://doi.org/10.1159/000517960

Author

Mogensen, Mette ; Hendel, Kristoffer ; Ung, Vilde ; Wenande, Emily ; Togsverd-Bo, Katrine ; Forman, Julie L. ; Haedersdal, Merete. / Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy : A Randomized Trial of Photoaged Skin. I: Dermatology. 2022 ; Bind 238. s. 422–429.

Bibtex

@article{97121ade696146de969131e2d719a989,
title = "Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy: A Randomized Trial of Photoaged Skin",
abstract = "Background and Objectives: Image-guided quantitative and semi-quantitative assessment of skin can potentially evaluate treatment efficacy. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are ideal for this purpose. This study assessed clinically relevant statistical changes in RCM and OCT features in photoaged skin after light and energy-based therapy. Methods: Novel statistical analyses were performed using OCT and RCM data collected during a previously published trial: a 12-week study of female decollete skin randomized to four areas treated with thulium laser (L), photodynamic therapy (PDT), combined L-PDT, and control. Eight semi-quantitative RCM scores of photodamage and OCT measurements of skin roughness, blood flow, and epidermal thickness (ET) were evaluated and compared to dermoscopy and clinical skin scores. In statistical analysis, estimated treatment difference (ETD) was calculated. Results: Twelve women with moderate to severe photodamage were included. RCM and OCT data demonstrated a trend towards rejuvenation of epidermis with increased ET, changes in skin surface, and improved honeycomb pattern in RCM. In angiographic OCT, non-significant changes towards more regular capillary meshes were shown, which matched a decline in appearance of gross telangiectasias in dermoscopy. Improved skin tone after laser and L-PDT was identified in RCM, showing less edged papillae in 36% and 45%, and lentigo number declined in 55% of patients after treatments in dermoscopy. Based on clinical scores, L-PDT provided the greatest clinical improvement, which corresponded to superior ETD outcomes in ET and edged papillae shown in OCT and RCM, respectively. Conclusion: Objective OCT and RCM assessment of skin rejuvenation was demonstrated in this study. Importantly, image-based improvements corresponded to favorable clinical skin scores and fewer photoaging characteristics in dermoscopy. Importantly, most changes did not reach statistical significance, prompting further studies and emphasizing the modest value of non-randomized, non-blinded anti-aging trials.",
keywords = "Reflectance confocal microscopy, Angiographic optical coherence tomography, Dermoscopy, Photoaging, Thulium laser, Photodynamic therapy, REJUVENATION, CANCER",
author = "Mette Mogensen and Kristoffer Hendel and Vilde Ung and Emily Wenande and Katrine Togsverd-Bo and Forman, {Julie L.} and Merete Haedersdal",
year = "2022",
doi = "10.1159/000517960",
language = "English",
volume = "238",
pages = "422–429",
journal = "Dermatology",
issn = "1018-8665",
publisher = "S Karger AG",

}

RIS

TY - JOUR

T1 - Assessing Light and Energy-Based Therapy by Optical Coherence Tomography and Reflectance Confocal Microscopy

T2 - A Randomized Trial of Photoaged Skin

AU - Mogensen, Mette

AU - Hendel, Kristoffer

AU - Ung, Vilde

AU - Wenande, Emily

AU - Togsverd-Bo, Katrine

AU - Forman, Julie L.

AU - Haedersdal, Merete

PY - 2022

Y1 - 2022

N2 - Background and Objectives: Image-guided quantitative and semi-quantitative assessment of skin can potentially evaluate treatment efficacy. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are ideal for this purpose. This study assessed clinically relevant statistical changes in RCM and OCT features in photoaged skin after light and energy-based therapy. Methods: Novel statistical analyses were performed using OCT and RCM data collected during a previously published trial: a 12-week study of female decollete skin randomized to four areas treated with thulium laser (L), photodynamic therapy (PDT), combined L-PDT, and control. Eight semi-quantitative RCM scores of photodamage and OCT measurements of skin roughness, blood flow, and epidermal thickness (ET) were evaluated and compared to dermoscopy and clinical skin scores. In statistical analysis, estimated treatment difference (ETD) was calculated. Results: Twelve women with moderate to severe photodamage were included. RCM and OCT data demonstrated a trend towards rejuvenation of epidermis with increased ET, changes in skin surface, and improved honeycomb pattern in RCM. In angiographic OCT, non-significant changes towards more regular capillary meshes were shown, which matched a decline in appearance of gross telangiectasias in dermoscopy. Improved skin tone after laser and L-PDT was identified in RCM, showing less edged papillae in 36% and 45%, and lentigo number declined in 55% of patients after treatments in dermoscopy. Based on clinical scores, L-PDT provided the greatest clinical improvement, which corresponded to superior ETD outcomes in ET and edged papillae shown in OCT and RCM, respectively. Conclusion: Objective OCT and RCM assessment of skin rejuvenation was demonstrated in this study. Importantly, image-based improvements corresponded to favorable clinical skin scores and fewer photoaging characteristics in dermoscopy. Importantly, most changes did not reach statistical significance, prompting further studies and emphasizing the modest value of non-randomized, non-blinded anti-aging trials.

AB - Background and Objectives: Image-guided quantitative and semi-quantitative assessment of skin can potentially evaluate treatment efficacy. Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) are ideal for this purpose. This study assessed clinically relevant statistical changes in RCM and OCT features in photoaged skin after light and energy-based therapy. Methods: Novel statistical analyses were performed using OCT and RCM data collected during a previously published trial: a 12-week study of female decollete skin randomized to four areas treated with thulium laser (L), photodynamic therapy (PDT), combined L-PDT, and control. Eight semi-quantitative RCM scores of photodamage and OCT measurements of skin roughness, blood flow, and epidermal thickness (ET) were evaluated and compared to dermoscopy and clinical skin scores. In statistical analysis, estimated treatment difference (ETD) was calculated. Results: Twelve women with moderate to severe photodamage were included. RCM and OCT data demonstrated a trend towards rejuvenation of epidermis with increased ET, changes in skin surface, and improved honeycomb pattern in RCM. In angiographic OCT, non-significant changes towards more regular capillary meshes were shown, which matched a decline in appearance of gross telangiectasias in dermoscopy. Improved skin tone after laser and L-PDT was identified in RCM, showing less edged papillae in 36% and 45%, and lentigo number declined in 55% of patients after treatments in dermoscopy. Based on clinical scores, L-PDT provided the greatest clinical improvement, which corresponded to superior ETD outcomes in ET and edged papillae shown in OCT and RCM, respectively. Conclusion: Objective OCT and RCM assessment of skin rejuvenation was demonstrated in this study. Importantly, image-based improvements corresponded to favorable clinical skin scores and fewer photoaging characteristics in dermoscopy. Importantly, most changes did not reach statistical significance, prompting further studies and emphasizing the modest value of non-randomized, non-blinded anti-aging trials.

KW - Reflectance confocal microscopy

KW - Angiographic optical coherence tomography

KW - Dermoscopy

KW - Photoaging

KW - Thulium laser

KW - Photodynamic therapy

KW - REJUVENATION

KW - CANCER

U2 - 10.1159/000517960

DO - 10.1159/000517960

M3 - Journal article

C2 - 34515098

VL - 238

SP - 422

EP - 429

JO - Dermatology

JF - Dermatology

SN - 1018-8665

ER -

ID: 279681089