Ascaris suum infection down-regulates inflammatory pathways in the pig intestine in vivo and in human dendritic cells in vitro

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Standard

Ascaris suum infection down-regulates inflammatory pathways in the pig intestine in vivo and in human dendritic cells in vitro. / Midttun, Helene L E; Acevedo, Nathalie; Skallerup, Per; Almeida, Sara; Skovgaard, Kerstin; Andresen, Lars; Skov, Søren; Caraballo, Luis; van Die, Irma; Jørgensen, Claus B; Fredholm, Merete; Thamsborg, Stig M; Nejsum, Peter; Williams, Andrew R.

I: The Journal of Infectious Diseases, Bind 217, Nr. 2, 2018, s. 310-319.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Midttun, HLE, Acevedo, N, Skallerup, P, Almeida, S, Skovgaard, K, Andresen, L, Skov, S, Caraballo, L, van Die, I, Jørgensen, CB, Fredholm, M, Thamsborg, SM, Nejsum, P & Williams, AR 2018, 'Ascaris suum infection down-regulates inflammatory pathways in the pig intestine in vivo and in human dendritic cells in vitro', The Journal of Infectious Diseases, bind 217, nr. 2, s. 310-319. https://doi.org/10.1093/infdis/jix585

APA

Midttun, H. L. E., Acevedo, N., Skallerup, P., Almeida, S., Skovgaard, K., Andresen, L., Skov, S., Caraballo, L., van Die, I., Jørgensen, C. B., Fredholm, M., Thamsborg, S. M., Nejsum, P., & Williams, A. R. (2018). Ascaris suum infection down-regulates inflammatory pathways in the pig intestine in vivo and in human dendritic cells in vitro. The Journal of Infectious Diseases, 217(2), 310-319. https://doi.org/10.1093/infdis/jix585

Vancouver

Midttun HLE, Acevedo N, Skallerup P, Almeida S, Skovgaard K, Andresen L o.a. Ascaris suum infection down-regulates inflammatory pathways in the pig intestine in vivo and in human dendritic cells in vitro. The Journal of Infectious Diseases. 2018;217(2):310-319. https://doi.org/10.1093/infdis/jix585

Author

Midttun, Helene L E ; Acevedo, Nathalie ; Skallerup, Per ; Almeida, Sara ; Skovgaard, Kerstin ; Andresen, Lars ; Skov, Søren ; Caraballo, Luis ; van Die, Irma ; Jørgensen, Claus B ; Fredholm, Merete ; Thamsborg, Stig M ; Nejsum, Peter ; Williams, Andrew R. / Ascaris suum infection down-regulates inflammatory pathways in the pig intestine in vivo and in human dendritic cells in vitro. I: The Journal of Infectious Diseases. 2018 ; Bind 217, Nr. 2. s. 310-319.

Bibtex

@article{ebf3860c22d4447a9fe2a8e4cea37122,

title = "Ascaris suum infection down-regulates inflammatory pathways in the pig intestine in vivo and in human dendritic cells in vitro",

abstract = "Ascaris suum is a helminth parasite of pigs closely related to its human counterpart, A. lumbricoides, which infects almost one billion people. Ascaris spp. is thought to modulate host immune and inflammatory responses, which may drive immune hyporesponsiveness during chronic infections. Using transcriptomic analysis, we show here that pigs with a chronic A. suum infection have a substantial suppression of inflammatory pathways in the intestinal mucosa, with a broad down-regulation of genes encoding cytokines and antigen-processing and co-stimulatory molecules. A. suum body fluid (ABF) supressed similar transcriptional pathways in human dendritic cells (DCs) in vitro. DCs exposed to ABF secreted minimal amounts of cytokines and had impaired production of cyclooxygengase-2, altered glucose metabolism, and a reduced capacity to induce IFN-γ production in T-cells. Our in vivo and in vitro data provide an insight into mucosal immune-modulation during Ascaris infection, and show that A. suum profoundly suppresses immune and inflammatory pathways.",

author = "Midttun, {Helene L E} and Nathalie Acevedo and Per Skallerup and Sara Almeida and Kerstin Skovgaard and Lars Andresen and S{\o}ren Skov and Luis Caraballo and {van Die}, Irma and J{\o}rgensen, {Claus B} and Merete Fredholm and Thamsborg, {Stig M} and Peter Nejsum and Williams, {Andrew R}",

note = "{\textcopyright} The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",

year = "2018",

doi = "10.1093/infdis/jix585",

language = "English",

volume = "217",

pages = "310--319",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "2",

}

RIS

TY - JOUR

T1 - Ascaris suum infection down-regulates inflammatory pathways in the pig intestine in vivo and in human dendritic cells in vitro

AU - Midttun, Helene L E

AU - Acevedo, Nathalie

AU - Skallerup, Per

AU - Almeida, Sara

AU - Skovgaard, Kerstin

AU - Andresen, Lars

AU - Skov, Søren

AU - Caraballo, Luis

AU - van Die, Irma

AU - Jørgensen, Claus B

AU - Fredholm, Merete

AU - Thamsborg, Stig M

AU - Nejsum, Peter

AU - Williams, Andrew R

PY - 2018

Y1 - 2018

N2 - Ascaris suum is a helminth parasite of pigs closely related to its human counterpart, A. lumbricoides, which infects almost one billion people. Ascaris spp. is thought to modulate host immune and inflammatory responses, which may drive immune hyporesponsiveness during chronic infections. Using transcriptomic analysis, we show here that pigs with a chronic A. suum infection have a substantial suppression of inflammatory pathways in the intestinal mucosa, with a broad down-regulation of genes encoding cytokines and antigen-processing and co-stimulatory molecules. A. suum body fluid (ABF) supressed similar transcriptional pathways in human dendritic cells (DCs) in vitro. DCs exposed to ABF secreted minimal amounts of cytokines and had impaired production of cyclooxygengase-2, altered glucose metabolism, and a reduced capacity to induce IFN-γ production in T-cells. Our in vivo and in vitro data provide an insight into mucosal immune-modulation during Ascaris infection, and show that A. suum profoundly suppresses immune and inflammatory pathways.

AB - Ascaris suum is a helminth parasite of pigs closely related to its human counterpart, A. lumbricoides, which infects almost one billion people. Ascaris spp. is thought to modulate host immune and inflammatory responses, which may drive immune hyporesponsiveness during chronic infections. Using transcriptomic analysis, we show here that pigs with a chronic A. suum infection have a substantial suppression of inflammatory pathways in the intestinal mucosa, with a broad down-regulation of genes encoding cytokines and antigen-processing and co-stimulatory molecules. A. suum body fluid (ABF) supressed similar transcriptional pathways in human dendritic cells (DCs) in vitro. DCs exposed to ABF secreted minimal amounts of cytokines and had impaired production of cyclooxygengase-2, altered glucose metabolism, and a reduced capacity to induce IFN-γ production in T-cells. Our in vivo and in vitro data provide an insight into mucosal immune-modulation during Ascaris infection, and show that A. suum profoundly suppresses immune and inflammatory pathways.

U2 - 10.1093/infdis/jix585

DO - 10.1093/infdis/jix585

M3 - Journal article

C2 - 29136163

VL - 217

SP - 310

EP - 319

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

ID: 185845779