Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology. / Bisgaard, Line S.; Christoffersen, Christina.

I: Current Opinion in Lipidology, Bind 30, Nr. 3, 2019, s. 212-217.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Bisgaard, LS & Christoffersen, C 2019, 'Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology', Current Opinion in Lipidology, bind 30, nr. 3, s. 212-217. https://doi.org/10.1097/MOL.0000000000000606

APA

Bisgaard, L. S., & Christoffersen, C. (2019). Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology. Current Opinion in Lipidology, 30(3), 212-217. https://doi.org/10.1097/MOL.0000000000000606

Vancouver

Bisgaard LS, Christoffersen C. Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology. Current Opinion in Lipidology. 2019;30(3):212-217. https://doi.org/10.1097/MOL.0000000000000606

Author

Bisgaard, Line S. ; Christoffersen, Christina. / Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology. I: Current Opinion in Lipidology. 2019 ; Bind 30, Nr. 3. s. 212-217.

Bibtex

@article{5b0a66cf84054451936d8a942d1566cc,
title = "Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology",
abstract = "Purpose of review In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest. Recent findings Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy). Summary Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.",
keywords = "apolipoprotein M, inflammation, nephropathy, sphingosine-1-phosphate, triglyceride",
author = "Bisgaard, {Line S.} and Christina Christoffersen",
year = "2019",
doi = "10.1097/MOL.0000000000000606",
language = "English",
volume = "30",
pages = "212--217",
journal = "Current Opinion in Lipidology",
issn = "0957-9672",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "3",

}

RIS

TY - JOUR

T1 - Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

AU - Bisgaard, Line S.

AU - Christoffersen, Christina

PY - 2019

Y1 - 2019

N2 - Purpose of review In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest. Recent findings Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy). Summary Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.

AB - Purpose of review In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest. Recent findings Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy). Summary Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.

KW - apolipoprotein M

KW - inflammation

KW - nephropathy

KW - sphingosine-1-phosphate

KW - triglyceride

U2 - 10.1097/MOL.0000000000000606

DO - 10.1097/MOL.0000000000000606

M3 - Review

C2 - 31008738

VL - 30

SP - 212

EP - 217

JO - Current Opinion in Lipidology

JF - Current Opinion in Lipidology

SN - 0957-9672

IS - 3

ER -

ID: 227785225