Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology. / Bisgaard, Line S.; Christoffersen, Christina.
I: Current Opinion in Lipidology, Bind 30, Nr. 3, 2019, s. 212-217.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology
AU - Bisgaard, Line S.
AU - Christoffersen, Christina
PY - 2019
Y1 - 2019
N2 - Purpose of review In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest. Recent findings Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy). Summary Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.
AB - Purpose of review In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest. Recent findings Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy). Summary Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.
KW - apolipoprotein M
KW - inflammation
KW - nephropathy
KW - sphingosine-1-phosphate
KW - triglyceride
U2 - 10.1097/MOL.0000000000000606
DO - 10.1097/MOL.0000000000000606
M3 - Review
C2 - 31008738
VL - 30
SP - 212
EP - 217
JO - Current Opinion in Lipidology
JF - Current Opinion in Lipidology
SN - 0957-9672
IS - 3
ER -
ID: 227785225