Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.
Udgave nummer1
Sider (fra-til)91-7
Antal sider7
StatusUdgivet - 2012

ID: 38431824