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Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury. / Guo, Zhen; Valenzuela Ripoll, Carla; Picataggi, Antonino; Rawnsley, David R.; Ozcan, Mualla; Chirinos, Julio A.; Chendamarai, Ezhilarasi; Girardi, Amanda; Riehl, Terrence; Evie, Hosannah; Diab, Ahmed; Kovacs, Attila; Hyrc, Krzysztof; Ma, Xiucui; Asnani, Aarti; Shewale, Swapnil V.; Scherrer-Crosbie, Marielle; Cowart, Lauren Ashley; Parks, John S.; Zhao, Lei; Gordon, David; Ramirez-Valle, Francisco; Margulies, Kenneth B.; Cappola, Thomas P.; Desai, Ankit A.; Pedersen, Lauren N.; Bergom, Carmen; Stitziel, Nathan O.; Rettig, Michael P.; DiPersio, John F.; Hajny, Stefan; Christoffersen, Christina; Diwan, Abhinav; Javaheri, Ali.
I:
JACC: Basic to Translational Science, Bind 8, Nr. 3, 2023, s. 340-355.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, DR, Ozcan, M, Chirinos, JA, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, SV, Scherrer-Crosbie, M, Cowart, LA, Parks, JS, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, KB, Cappola, TP, Desai, AA, Pedersen, LN, Bergom, C, Stitziel, NO, Rettig, MP, DiPersio, JF
, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, '
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury',
JACC: Basic to Translational Science, bind 8, nr. 3, s. 340-355.
https://doi.org/10.1016/j.jacbts.2022.09.010APA
Guo, Z., Valenzuela Ripoll, C., Picataggi, A., Rawnsley, D. R., Ozcan, M., Chirinos, J. A., Chendamarai, E., Girardi, A., Riehl, T., Evie, H., Diab, A., Kovacs, A., Hyrc, K., Ma, X., Asnani, A., Shewale, S. V., Scherrer-Crosbie, M., Cowart, L. A., Parks, J. S., ... Javaheri, A. (2023).
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury.
JACC: Basic to Translational Science,
8(3), 340-355.
https://doi.org/10.1016/j.jacbts.2022.09.010Vancouver
Guo Z, Valenzuela Ripoll C, Picataggi A, Rawnsley DR, Ozcan M, Chirinos JA o.a.
Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury.
JACC: Basic to Translational Science. 2023;8(3):340-355.
https://doi.org/10.1016/j.jacbts.2022.09.010Author
Guo, Zhen ; Valenzuela Ripoll, Carla ; Picataggi, Antonino ; Rawnsley, David R. ; Ozcan, Mualla ; Chirinos, Julio A. ; Chendamarai, Ezhilarasi ; Girardi, Amanda ; Riehl, Terrence ; Evie, Hosannah ; Diab, Ahmed ; Kovacs, Attila ; Hyrc, Krzysztof ; Ma, Xiucui ; Asnani, Aarti ; Shewale, Swapnil V. ; Scherrer-Crosbie, Marielle ; Cowart, Lauren Ashley ; Parks, John S. ; Zhao, Lei ; Gordon, David ; Ramirez-Valle, Francisco ; Margulies, Kenneth B. ; Cappola, Thomas P. ; Desai, Ankit A. ; Pedersen, Lauren N. ; Bergom, Carmen ; Stitziel, Nathan O. ; Rettig, Michael P. ; DiPersio, John F. ; Hajny, Stefan ; Christoffersen, Christina ; Diwan, Abhinav ; Javaheri, Ali. / Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury. I: JACC: Basic to Translational Science. 2023 ; Bind 8, Nr. 3. s. 340-355.
Bibtex
@article{95d1089f6a8f406eb690fec872101a75,
title = "Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury",
abstract = "Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM in mice and humans, that ApoM is inversely associated with mortality in patients with anthracycline-induced heart failure, and ApoM heterozygosity in mice increases Dox-induced mortality. In the setting of Dox stress, our studies suggest ApoM can help sustain myocardial autophagic flux in a post-transcriptional manner, attenuate Dox cardiotoxicity, and prevent lysosomal injury.",
keywords = "anthracycline, apolipoprotein M, autophagy, cardiomyopathy, TFEB",
author = "Zhen Guo and {Valenzuela Ripoll}, Carla and Antonino Picataggi and Rawnsley, {David R.} and Mualla Ozcan and Chirinos, {Julio A.} and Ezhilarasi Chendamarai and Amanda Girardi and Terrence Riehl and Hosannah Evie and Ahmed Diab and Attila Kovacs and Krzysztof Hyrc and Xiucui Ma and Aarti Asnani and Shewale, {Swapnil V.} and Marielle Scherrer-Crosbie and Cowart, {Lauren Ashley} and Parks, {John S.} and Lei Zhao and David Gordon and Francisco Ramirez-Valle and Margulies, {Kenneth B.} and Cappola, {Thomas P.} and Desai, {Ankit A.} and Pedersen, {Lauren N.} and Carmen Bergom and Stitziel, {Nathan O.} and Rettig, {Michael P.} and DiPersio, {John F.} and Stefan Hajny and Christina Christoffersen and Abhinav Diwan and Ali Javaheri",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.jacbts.2022.09.010",
language = "English",
volume = "8",
pages = "340--355",
journal = "JACC: Basic to Translational Science",
issn = "2452-302X",
publisher = "Elsevier",
number = "3",
}
RIS
TY - JOUR
T1 - Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury
AU - Guo, Zhen
AU - Valenzuela Ripoll, Carla
AU - Picataggi, Antonino
AU - Rawnsley, David R.
AU - Ozcan, Mualla
AU - Chirinos, Julio A.
AU - Chendamarai, Ezhilarasi
AU - Girardi, Amanda
AU - Riehl, Terrence
AU - Evie, Hosannah
AU - Diab, Ahmed
AU - Kovacs, Attila
AU - Hyrc, Krzysztof
AU - Ma, Xiucui
AU - Asnani, Aarti
AU - Shewale, Swapnil V.
AU - Scherrer-Crosbie, Marielle
AU - Cowart, Lauren Ashley
AU - Parks, John S.
AU - Zhao, Lei
AU - Gordon, David
AU - Ramirez-Valle, Francisco
AU - Margulies, Kenneth B.
AU - Cappola, Thomas P.
AU - Desai, Ankit A.
AU - Pedersen, Lauren N.
AU - Bergom, Carmen
AU - Stitziel, Nathan O.
AU - Rettig, Michael P.
AU - DiPersio, John F.
AU - Hajny, Stefan
AU - Christoffersen, Christina
AU - Diwan, Abhinav
AU - Javaheri, Ali
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM in mice and humans, that ApoM is inversely associated with mortality in patients with anthracycline-induced heart failure, and ApoM heterozygosity in mice increases Dox-induced mortality. In the setting of Dox stress, our studies suggest ApoM can help sustain myocardial autophagic flux in a post-transcriptional manner, attenuate Dox cardiotoxicity, and prevent lysosomal injury.
AB - Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM in mice and humans, that ApoM is inversely associated with mortality in patients with anthracycline-induced heart failure, and ApoM heterozygosity in mice increases Dox-induced mortality. In the setting of Dox stress, our studies suggest ApoM can help sustain myocardial autophagic flux in a post-transcriptional manner, attenuate Dox cardiotoxicity, and prevent lysosomal injury.
KW - anthracycline
KW - apolipoprotein M
KW - autophagy
KW - cardiomyopathy
KW - TFEB
UR - http://www.scopus.com/inward/record.url?scp=85150029297&partnerID=8YFLogxK
U2 - 10.1016/j.jacbts.2022.09.010
DO - 10.1016/j.jacbts.2022.09.010
M3 - Journal article
C2 - 37034289
AN - SCOPUS:85150029297
VL - 8
SP - 340
EP - 355
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
SN - 2452-302X
IS - 3
ER -
