Angiogenic response to passive movement and active exercise in individuals with peripheral arterial disease
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Angiogenic response to passive movement and active exercise in individuals with peripheral arterial disease. / Høier, Birgitte; Walker, Meegan; Passos, Madla; Walker, Philip J; Green, Anita; Bangsbo, Jens; Askew, Christopher D; Hellsten, Ylva.
I: Journal of Applied Physiology, Bind 115, Nr. 12, 2013, s. 1777-1787.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Angiogenic response to passive movement and active exercise in individuals with peripheral arterial disease
AU - Høier, Birgitte
AU - Walker, Meegan
AU - Passos, Madla
AU - Walker, Philip J
AU - Green, Anita
AU - Bangsbo, Jens
AU - Askew, Christopher D
AU - Hellsten, Ylva
N1 - CURIS 2013 NEXS 268
PY - 2013
Y1 - 2013
N2 - Peripheral arterial disease (PAD) is caused by atherosclerosis and is associated with microcirculatory impairments in skeletal muscle. The present study evaluated the angiogenic response to exercise and passive movement in skeletal muscle of PAD patients compared to healthy control subjects. Twenty-one PAD patients and 17 aged controls were randomly assigned to either a passive movement or an active exercise study. Interstitial fluid microdialysate and tissue samples were obtained from the thigh skeletal muscle. Muscle dialysate vascular endothelial growth factor (VEGF) levels were modestly increased in response to either passive movement or active exercise in both subject groups. The basal muscle dialysate level of the angiostatic factor trombospondin-1 protein (TSP-1) was markedly higher (P
AB - Peripheral arterial disease (PAD) is caused by atherosclerosis and is associated with microcirculatory impairments in skeletal muscle. The present study evaluated the angiogenic response to exercise and passive movement in skeletal muscle of PAD patients compared to healthy control subjects. Twenty-one PAD patients and 17 aged controls were randomly assigned to either a passive movement or an active exercise study. Interstitial fluid microdialysate and tissue samples were obtained from the thigh skeletal muscle. Muscle dialysate vascular endothelial growth factor (VEGF) levels were modestly increased in response to either passive movement or active exercise in both subject groups. The basal muscle dialysate level of the angiostatic factor trombospondin-1 protein (TSP-1) was markedly higher (P
U2 - 10.1152/japplphysiol.00979.2013
DO - 10.1152/japplphysiol.00979.2013
M3 - Journal article
C2 - 24157526
VL - 115
SP - 1777
EP - 1787
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 8750-7587
IS - 12
ER -
ID: 61854062