Anaphase onset before complete DNA replication with intact checkpoint responses.

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Standard

Anaphase onset before complete DNA replication with intact checkpoint responses. / Torres-Rosell, Jordi; De Piccoli, Giacomo; Cordon-Preciado, Violeta; Farmer, Sarah; Jarmuz, Adam; Machin, Felix; Pasero, Philippe; Lisby, Michael; Haber, James E; Aragón, Luis.

I: Science, Bind 315, Nr. 5817, 2007, s. 1411-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Torres-Rosell, J, De Piccoli, G, Cordon-Preciado, V, Farmer, S, Jarmuz, A, Machin, F, Pasero, P, Lisby, M, Haber, JE & Aragón, L 2007, 'Anaphase onset before complete DNA replication with intact checkpoint responses.', Science, bind 315, nr. 5817, s. 1411-5. https://doi.org/10.1126/science.1134025

APA

Torres-Rosell, J., De Piccoli, G., Cordon-Preciado, V., Farmer, S., Jarmuz, A., Machin, F., Pasero, P., Lisby, M., Haber, J. E., & Aragón, L. (2007). Anaphase onset before complete DNA replication with intact checkpoint responses. Science, 315(5817), 1411-5. https://doi.org/10.1126/science.1134025

Vancouver

Torres-Rosell J, De Piccoli G, Cordon-Preciado V, Farmer S, Jarmuz A, Machin F o.a. Anaphase onset before complete DNA replication with intact checkpoint responses. Science. 2007;315(5817):1411-5. https://doi.org/10.1126/science.1134025

Author

Torres-Rosell, Jordi ; De Piccoli, Giacomo ; Cordon-Preciado, Violeta ; Farmer, Sarah ; Jarmuz, Adam ; Machin, Felix ; Pasero, Philippe ; Lisby, Michael ; Haber, James E ; Aragón, Luis. / Anaphase onset before complete DNA replication with intact checkpoint responses. I: Science. 2007 ; Bind 315, Nr. 5817. s. 1411-5.

Bibtex

@article{35053c60124211ddbee902004c4f4f50,
title = "Anaphase onset before complete DNA replication with intact checkpoint responses.",
abstract = "Cellular checkpoints prevent mitosis in the presence of stalled replication forks. Whether checkpoints also ensure the completion of DNA replication before mitosis is unknown. Here, we show that in yeast smc5-smc6 mutants, which are related to cohesin and condensin, replication is delayed, most significantly at natural replication-impeding loci like the ribosomal DNA gene cluster. In the absence of Smc5-Smc6, chromosome nondisjunction occurs as a consequence of mitotic entry with unfinished replication despite intact checkpoint responses. Eliminating processes that obstruct replication fork progression restores the temporal uncoupling between replication and segregation in smc5-smc6 mutants. We propose that the completion of replication is not under the surveillance of known checkpoints",
author = "Jordi Torres-Rosell and {De Piccoli}, Giacomo and Violeta Cordon-Preciado and Sarah Farmer and Adam Jarmuz and Felix Machin and Philippe Pasero and Michael Lisby and Haber, {James E} and Luis Arag{\'o}n",
note = "Keywords: Anaphase; Cell Cycle Proteins; Chromosome Segregation; Chromosomes, Fungal; DNA Breaks, Double-Stranded; DNA Damage; DNA Replication; DNA, Fungal; DNA, Ribosomal; Genes, Fungal; Genes, rRNA; Metaphase; Mitosis; Models, Genetic; Mutation; Nondisjunction, Genetic; Protein-Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins",
year = "2007",
doi = "10.1126/science.1134025",
language = "English",
volume = "315",
pages = "1411--5",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5817",

}

RIS

TY - JOUR

T1 - Anaphase onset before complete DNA replication with intact checkpoint responses.

AU - Torres-Rosell, Jordi

AU - De Piccoli, Giacomo

AU - Cordon-Preciado, Violeta

AU - Farmer, Sarah

AU - Jarmuz, Adam

AU - Machin, Felix

AU - Pasero, Philippe

AU - Lisby, Michael

AU - Haber, James E

AU - Aragón, Luis

N1 - Keywords: Anaphase; Cell Cycle Proteins; Chromosome Segregation; Chromosomes, Fungal; DNA Breaks, Double-Stranded; DNA Damage; DNA Replication; DNA, Fungal; DNA, Ribosomal; Genes, Fungal; Genes, rRNA; Metaphase; Mitosis; Models, Genetic; Mutation; Nondisjunction, Genetic; Protein-Serine-Threonine Kinases; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins

PY - 2007

Y1 - 2007

N2 - Cellular checkpoints prevent mitosis in the presence of stalled replication forks. Whether checkpoints also ensure the completion of DNA replication before mitosis is unknown. Here, we show that in yeast smc5-smc6 mutants, which are related to cohesin and condensin, replication is delayed, most significantly at natural replication-impeding loci like the ribosomal DNA gene cluster. In the absence of Smc5-Smc6, chromosome nondisjunction occurs as a consequence of mitotic entry with unfinished replication despite intact checkpoint responses. Eliminating processes that obstruct replication fork progression restores the temporal uncoupling between replication and segregation in smc5-smc6 mutants. We propose that the completion of replication is not under the surveillance of known checkpoints

AB - Cellular checkpoints prevent mitosis in the presence of stalled replication forks. Whether checkpoints also ensure the completion of DNA replication before mitosis is unknown. Here, we show that in yeast smc5-smc6 mutants, which are related to cohesin and condensin, replication is delayed, most significantly at natural replication-impeding loci like the ribosomal DNA gene cluster. In the absence of Smc5-Smc6, chromosome nondisjunction occurs as a consequence of mitotic entry with unfinished replication despite intact checkpoint responses. Eliminating processes that obstruct replication fork progression restores the temporal uncoupling between replication and segregation in smc5-smc6 mutants. We propose that the completion of replication is not under the surveillance of known checkpoints

U2 - 10.1126/science.1134025

DO - 10.1126/science.1134025

M3 - Journal article

C2 - 17347440

VL - 315

SP - 1411

EP - 1415

JO - Science

JF - Science

SN - 0036-8075

IS - 5817

ER -

ID: 3802194