Adipose MDM2 regulates systemic insulin sensitivity

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Adipose MDM2 regulates systemic insulin sensitivity. / Hallenborg, Philip; Jensen, Benjamin Anderschou Holbech; Fjære, Even; Petersen, Rasmus Koefoed; Belmaâti, Mohammed Samir; Rasmussen, Sarah Søndergård; Gunnarsson, Jon Petur; Lauritzen, Pernille; Cheng, Kenneth King Yip; Hermansson, Martin; Sonne, Si Brask; Ejsing, Christer S.; Xu, Aimin; Kratchmarova, Irina; Krüger, Marcus; Madsen, Lise; Kristiansen, Karsten; Blagoev, Blagoy.

I: Scientific Reports, Bind 11, 21839, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hallenborg, P, Jensen, BAH, Fjære, E, Petersen, RK, Belmaâti, MS, Rasmussen, SS, Gunnarsson, JP, Lauritzen, P, Cheng, KKY, Hermansson, M, Sonne, SB, Ejsing, CS, Xu, A, Kratchmarova, I, Krüger, M, Madsen, L, Kristiansen, K & Blagoev, B 2021, 'Adipose MDM2 regulates systemic insulin sensitivity', Scientific Reports, bind 11, 21839. https://doi.org/10.1038/s41598-021-01240-3

APA

Hallenborg, P., Jensen, B. A. H., Fjære, E., Petersen, R. K., Belmaâti, M. S., Rasmussen, S. S., Gunnarsson, J. P., Lauritzen, P., Cheng, K. K. Y., Hermansson, M., Sonne, S. B., Ejsing, C. S., Xu, A., Kratchmarova, I., Krüger, M., Madsen, L., Kristiansen, K., & Blagoev, B. (2021). Adipose MDM2 regulates systemic insulin sensitivity. Scientific Reports, 11, [21839]. https://doi.org/10.1038/s41598-021-01240-3

Vancouver

Hallenborg P, Jensen BAH, Fjære E, Petersen RK, Belmaâti MS, Rasmussen SS o.a. Adipose MDM2 regulates systemic insulin sensitivity. Scientific Reports. 2021;11. 21839. https://doi.org/10.1038/s41598-021-01240-3

Author

Hallenborg, Philip ; Jensen, Benjamin Anderschou Holbech ; Fjære, Even ; Petersen, Rasmus Koefoed ; Belmaâti, Mohammed Samir ; Rasmussen, Sarah Søndergård ; Gunnarsson, Jon Petur ; Lauritzen, Pernille ; Cheng, Kenneth King Yip ; Hermansson, Martin ; Sonne, Si Brask ; Ejsing, Christer S. ; Xu, Aimin ; Kratchmarova, Irina ; Krüger, Marcus ; Madsen, Lise ; Kristiansen, Karsten ; Blagoev, Blagoy. / Adipose MDM2 regulates systemic insulin sensitivity. I: Scientific Reports. 2021 ; Bind 11.

Bibtex

@article{3441ed27191742c2ab50fb752e6c27df,

title = "Adipose MDM2 regulates systemic insulin sensitivity",

abstract = "The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffer from overt obesity, glucose intolerance, and hepatic steatosis. These mice had decreased levels of circulating palmitoleic acid [non-esterified fatty acid (NEFA) 16:1] concomitant with impaired visceral adipose tissue expression of Scd1 and Ffar4. A similar decrease in Scd and Ffar4 expression was found in in vitro differentiated adipocytes with perturbed MDM2 expression. Lowered MDM2 levels led to nuclear exclusion of the transcriptional cofactors, MORC2 and LIPIN1, and thereby possibly hampered adipocyte function by antagonizing LIPIN1-mediated PPARγ coactivation. Collectively, these data argue for a hitherto unknown interplay between MDM2 and MORC2/LIPIN1 involved in balancing adipocyte function.",

author = "Philip Hallenborg and Jensen, {Benjamin Anderschou Holbech} and Even Fj{\ae}re and Petersen, {Rasmus Koefoed} and Belma{\^a}ti, {Mohammed Samir} and Rasmussen, {Sarah S{\o}nderg{\aa}rd} and Gunnarsson, {Jon Petur} and Pernille Lauritzen and Cheng, {Kenneth King Yip} and Martin Hermansson and Sonne, {Si Brask} and Ejsing, {Christer S.} and Aimin Xu and Irina Kratchmarova and Marcus Kr{\"u}ger and Lise Madsen and Karsten Kristiansen and Blagoy Blagoev",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

doi = "10.1038/s41598-021-01240-3",

language = "English",

volume = "11",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Adipose MDM2 regulates systemic insulin sensitivity

AU - Hallenborg, Philip

AU - Jensen, Benjamin Anderschou Holbech

AU - Fjære, Even

AU - Petersen, Rasmus Koefoed

AU - Belmaâti, Mohammed Samir

AU - Rasmussen, Sarah Søndergård

AU - Gunnarsson, Jon Petur

AU - Lauritzen, Pernille

AU - Cheng, Kenneth King Yip

AU - Hermansson, Martin

AU - Sonne, Si Brask

AU - Ejsing, Christer S.

AU - Xu, Aimin

AU - Kratchmarova, Irina

AU - Krüger, Marcus

AU - Madsen, Lise

AU - Kristiansen, Karsten

AU - Blagoev, Blagoy

PY - 2021

Y1 - 2021

N2 - The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffer from overt obesity, glucose intolerance, and hepatic steatosis. These mice had decreased levels of circulating palmitoleic acid [non-esterified fatty acid (NEFA) 16:1] concomitant with impaired visceral adipose tissue expression of Scd1 and Ffar4. A similar decrease in Scd and Ffar4 expression was found in in vitro differentiated adipocytes with perturbed MDM2 expression. Lowered MDM2 levels led to nuclear exclusion of the transcriptional cofactors, MORC2 and LIPIN1, and thereby possibly hampered adipocyte function by antagonizing LIPIN1-mediated PPARγ coactivation. Collectively, these data argue for a hitherto unknown interplay between MDM2 and MORC2/LIPIN1 involved in balancing adipocyte function.

AB - The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffer from overt obesity, glucose intolerance, and hepatic steatosis. These mice had decreased levels of circulating palmitoleic acid [non-esterified fatty acid (NEFA) 16:1] concomitant with impaired visceral adipose tissue expression of Scd1 and Ffar4. A similar decrease in Scd and Ffar4 expression was found in in vitro differentiated adipocytes with perturbed MDM2 expression. Lowered MDM2 levels led to nuclear exclusion of the transcriptional cofactors, MORC2 and LIPIN1, and thereby possibly hampered adipocyte function by antagonizing LIPIN1-mediated PPARγ coactivation. Collectively, these data argue for a hitherto unknown interplay between MDM2 and MORC2/LIPIN1 involved in balancing adipocyte function.

U2 - 10.1038/s41598-021-01240-3

DO - 10.1038/s41598-021-01240-3

M3 - Journal article

C2 - 34750429

AN - SCOPUS:85118601244

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 21839

ER -

ID: 286415031