ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy

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ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy. / Guo, Ling T; Shelton, G Diane; Wewer, Ulla M; Engvall, Eva.

I: Neuromuscular Disorders, Bind 15, Nr. 11, 01.11.2005, s. 786-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Guo, LT, Shelton, GD, Wewer, UM & Engvall, E 2005, 'ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy', Neuromuscular Disorders, bind 15, nr. 11, s. 786-9. https://doi.org/10.1016/j.nmd.2005.06.019

APA

Guo, L. T., Shelton, G. D., Wewer, U. M., & Engvall, E. (2005). ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy. Neuromuscular Disorders, 15(11), 786-9. https://doi.org/10.1016/j.nmd.2005.06.019

Vancouver

Guo LT, Shelton GD, Wewer UM, Engvall E. ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy. Neuromuscular Disorders. 2005 nov. 1;15(11):786-9. https://doi.org/10.1016/j.nmd.2005.06.019

Author

Guo, Ling T ; Shelton, G Diane ; Wewer, Ulla M ; Engvall, Eva. / ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy. I: Neuromuscular Disorders. 2005 ; Bind 15, Nr. 11. s. 786-9.

Bibtex

@article{7053e06397734b0e9d8e48681d56a3e9,

title = "ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy",

abstract = "We have recently shown that overexpression of ADAM12 results in increased muscle regeneration and significantly reduced pathology in mdx, dystrophin deficient mice. In the present study, we tested the effect of overexpressing ADAM12 in dy(W) laminin-deficient mice. dy mice have a very severe clinical phenotype and would be expected to benefit greatly from enhanced regeneration. We found that dy(W) mice overexpressing ADAM12 indeed have increased muscle regeneration, as evidenced by increased numbers of muscle fibers expressing fetal myosin. However, overexpression of ADAM12 had no significant effect on overall health, as evidenced by body weight, and did not improve muscle pathology.",

keywords = "ADAM Proteins, Age Factors, Animals, Blotting, Western, Body Weight, Disease Models, Animal, Gene Expression Regulation, Immunohistochemistry, Laminin, Mice, Mice, Knockout, Muscular Dystrophy, Animal, Regeneration",

author = "Guo, {Ling T} and Shelton, {G Diane} and Wewer, {Ulla M} and Eva Engvall",

year = "2005",

month = nov,

day = "1",

doi = "10.1016/j.nmd.2005.06.019",

language = "English",

volume = "15",

pages = "786--9",

journal = "Journal of Neuromuscular Diseases",

issn = "0960-8966",

publisher = "Elsevier",

number = "11",

}

RIS

TY - JOUR

T1 - ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy

AU - Guo, Ling T

AU - Shelton, G Diane

AU - Wewer, Ulla M

AU - Engvall, Eva

PY - 2005/11/1

Y1 - 2005/11/1

N2 - We have recently shown that overexpression of ADAM12 results in increased muscle regeneration and significantly reduced pathology in mdx, dystrophin deficient mice. In the present study, we tested the effect of overexpressing ADAM12 in dy(W) laminin-deficient mice. dy mice have a very severe clinical phenotype and would be expected to benefit greatly from enhanced regeneration. We found that dy(W) mice overexpressing ADAM12 indeed have increased muscle regeneration, as evidenced by increased numbers of muscle fibers expressing fetal myosin. However, overexpression of ADAM12 had no significant effect on overall health, as evidenced by body weight, and did not improve muscle pathology.

AB - We have recently shown that overexpression of ADAM12 results in increased muscle regeneration and significantly reduced pathology in mdx, dystrophin deficient mice. In the present study, we tested the effect of overexpressing ADAM12 in dy(W) laminin-deficient mice. dy mice have a very severe clinical phenotype and would be expected to benefit greatly from enhanced regeneration. We found that dy(W) mice overexpressing ADAM12 indeed have increased muscle regeneration, as evidenced by increased numbers of muscle fibers expressing fetal myosin. However, overexpression of ADAM12 had no significant effect on overall health, as evidenced by body weight, and did not improve muscle pathology.

KW - ADAM Proteins

KW - Age Factors

KW - Animals

KW - Blotting, Western

KW - Body Weight

KW - Disease Models, Animal

KW - Gene Expression Regulation

KW - Immunohistochemistry

KW - Laminin

KW - Mice

KW - Mice, Knockout

KW - Muscular Dystrophy, Animal

KW - Regeneration

U2 - 10.1016/j.nmd.2005.06.019

DO - 10.1016/j.nmd.2005.06.019

M3 - Journal article

C2 - 16198565

VL - 15

SP - 786

EP - 789

JO - Journal of Neuromuscular Diseases

JF - Journal of Neuromuscular Diseases

SN - 0960-8966

IS - 11

ER -

ID: 34325158