ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice
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ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice. / Kronqvist, Pauliina; Kawaguchi, Nobuko; Albrechtsen, Reidar; Xu, Xiufeng; Schrøder, Henrik Daa; Moghadaszadeh, Behzad; Nielsen, Finn Cilius; Frohlich, Camilla; Engvall, Eva; Wewer, Ulla M.
I: American Journal of Pathology, Bind 161, Nr. 5, 01.11.2002, s. 1535-40.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - ADAM12 alleviates the skeletal muscle pathology in mdx dystrophic mice
AU - Kronqvist, Pauliina
AU - Kawaguchi, Nobuko
AU - Albrechtsen, Reidar
AU - Xu, Xiufeng
AU - Schrøder, Henrik Daa
AU - Moghadaszadeh, Behzad
AU - Nielsen, Finn Cilius
AU - Frohlich, Camilla
AU - Engvall, Eva
AU - Wewer, Ulla M
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Muscular dystrophy is characterized by muscle degeneration and insufficient regeneration and replacement of muscle fibers by connective tissue. New therapeutic strategies directed toward various forms of muscular dystrophy are needed to preserve muscle mass and promote regeneration. In this study we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. These studies demonstrate that ADAM12 directly or indirectly contributes to muscle cell regeneration, stability, and survival.
AB - Muscular dystrophy is characterized by muscle degeneration and insufficient regeneration and replacement of muscle fibers by connective tissue. New therapeutic strategies directed toward various forms of muscular dystrophy are needed to preserve muscle mass and promote regeneration. In this study we examined the role of the transmembrane ADAM12, a disintegrin and metalloprotease, which is normally associated with development and regeneration of skeletal muscle. We demonstrate that ADAM12 overexpression in the dystrophin-deficient mdx mice alleviated the muscle pathology in these animals, as evidenced by less muscle cell necrosis and inflammation, lower levels of serum creatine kinase, and less uptake of Evans Blue dye into muscle fibers. These studies demonstrate that ADAM12 directly or indirectly contributes to muscle cell regeneration, stability, and survival.
KW - ADAM Proteins
KW - Animals
KW - Humans
KW - Inflammation
KW - Membrane Proteins
KW - Metalloendopeptidases
KW - Mice
KW - Mice, Inbred mdx
KW - Mice, Transgenic
KW - Muscle, Skeletal
KW - Muscular Dystrophies
KW - Necrosis
U2 - 10.1016/S0002-9440(10)64431-8
DO - 10.1016/S0002-9440(10)64431-8
M3 - Journal article
C2 - 12414501
VL - 161
SP - 1535
EP - 1540
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 5
ER -
ID: 34325662