Acute posterior multifocal placoid pigment epitheliopathy resembling multiple sclerosis
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A 23-year-old man presented with right eye blurred vision; he was diagnosed with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), and his symptoms resolved with prednisolone. Two months later, he developed a right arm weakness that resolved after 3 weeks. MR scan of brain identified changes suggesting multiple sclerosis, with four hyperintense FLAIR lesions; there was contrast enhancement of two lesions and no diffusion restriction. Cerebrospinal fluid showed mononuclear pleocytosis. We eventually diagnosed these as APMPPE-associated CNS lesions. APMPPE is a rare inflammatory chorioretinopathy that rarely can resemble multiple sclerosis clinically and radiologically.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Practical Neurology |
Vol/bind | 22 |
Udgave nummer | 6 |
Sider (fra-til) | 515-517 |
Antal sider | 3 |
ISSN | 1474-7758 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
SEM, AI, KH, AL and SH report no conflicts of interest. JRC reports receiving speaker honoraria from Biogen and being a member of the steering committee of the DanNORMS study ( NCT04688788 ) and receiving grants from the Medicine Fund of the Danish Regions.
Publisher Copyright:
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.
ID: 327139549