Activated human CD4 T cells express transporters for both cysteine and cystine
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Activated human CD4 T cells express transporters for both cysteine and cystine. / Levring, Trine Bøegh; Hansen, Ann Kathrine; Nielsen, Bodil Lisbeth; Kongsbak, Martin; von Essen, Marina Rode; Woetmann, Anders; Odum, Niels; Bonefeld, Charlotte Menné; Geisler, Carsten.
I: Scientific Reports, Bind 2, 266, 14.02.2012.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Activated human CD4 T cells express transporters for both cysteine and cystine
AU - Levring, Trine Bøegh
AU - Hansen, Ann Kathrine
AU - Nielsen, Bodil Lisbeth
AU - Kongsbak, Martin
AU - von Essen, Marina Rode
AU - Woetmann, Anders
AU - Odum, Niels
AU - Bonefeld, Charlotte Menné
AU - Geisler, Carsten
PY - 2012/2/14
Y1 - 2012/2/14
N2 - Because naïve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine is required and how T cells meet this requirement. We found that early activation of T cells is independent of exogenous cystine/cysteine, whereas T cell proliferation is strictly dependent of uptake of exogenous cystine/cysteine. Naïve T cells express no or very low levels of both cystine and cysteine transporters. However, we found that these transporters become strongly up-regulated during T cell activation and provide activated T cells with the required amount of cystine/cysteine needed for T cell proliferation. Thus, T cells are equipped with mechanisms that allow T cell activation and proliferation independently of cysteine generated by antigen presenting cells.
AB - Because naïve T cells are unable to import cystine due to the absence of cystine transporters, it has been suggested that T cell activation is dependent on cysteine generated by antigen presenting cells. The aim of this study was to determine at which phases during T cell activation exogenous cystine/cysteine is required and how T cells meet this requirement. We found that early activation of T cells is independent of exogenous cystine/cysteine, whereas T cell proliferation is strictly dependent of uptake of exogenous cystine/cysteine. Naïve T cells express no or very low levels of both cystine and cysteine transporters. However, we found that these transporters become strongly up-regulated during T cell activation and provide activated T cells with the required amount of cystine/cysteine needed for T cell proliferation. Thus, T cells are equipped with mechanisms that allow T cell activation and proliferation independently of cysteine generated by antigen presenting cells.
U2 - 10.1038/srep00266
DO - 10.1038/srep00266
M3 - Journal article
C2 - 22355778
VL - 2
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 266
ER -
ID: 38170326