A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe
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A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe. / Mocroft, A; Reiss, P; Rakhmanova, A; Banhegyi, D; Phillips, A N; De Wit, S; Ristola, M; Lundgren, J D; Grarup, J; Kirk, O; EuroSIDA in EuroCoord.
I: Infection: A Journal of Infectious Diseases, Bind 42, Nr. 4, 08.2014, s. 757-762.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe
AU - Mocroft, A
AU - Reiss, P
AU - Rakhmanova, A
AU - Banhegyi, D
AU - Phillips, A N
AU - De Wit, S
AU - Ristola, M
AU - Lundgren, J D
AU - Grarup, J
AU - Kirk, O
AU - EuroSIDA in EuroCoord
PY - 2014/8
Y1 - 2014/8
N2 - ATRIPLA is licensed for use only in HIV-positive persons whose viral loads <50 for ≥ 3 months. We investigated the use of ATRIPLA as first-line antiretroviral therapy (ART) in EuroSIDA using a web-based survey performed in Autumn 2012. 96/112 clinics (85.7 %) completed the survey. Recommendations when initiating first-line ART was TRUVADA plus efavirenz in 36 (37.5 %), ATRIPLA in 35 (36.5 %), a different first-line regimen in 12 clinics (12.5 %), and no recommendation in 7 clinics (7.3 %). ATRIPLA was commonest in Northern (15/21 clinics; 71.4 %), and least common in Eastern Europe (2/31 clinics; 6.5 %; p < 0.0001). Over one-third of the participating clinics in this survey were using ATRIPLA as first-line antiretroviral therapy, despite EMA recommendations.
AB - ATRIPLA is licensed for use only in HIV-positive persons whose viral loads <50 for ≥ 3 months. We investigated the use of ATRIPLA as first-line antiretroviral therapy (ART) in EuroSIDA using a web-based survey performed in Autumn 2012. 96/112 clinics (85.7 %) completed the survey. Recommendations when initiating first-line ART was TRUVADA plus efavirenz in 36 (37.5 %), ATRIPLA in 35 (36.5 %), a different first-line regimen in 12 clinics (12.5 %), and no recommendation in 7 clinics (7.3 %). ATRIPLA was commonest in Northern (15/21 clinics; 71.4 %), and least common in Eastern Europe (2/31 clinics; 6.5 %; p < 0.0001). Over one-third of the participating clinics in this survey were using ATRIPLA as first-line antiretroviral therapy, despite EMA recommendations.
KW - Adenine
KW - Adult
KW - Anti-HIV Agents
KW - Cohort Studies
KW - Data Collection
KW - Deoxycytidine
KW - Drug Combinations
KW - Drug Utilization
KW - Europe
KW - Female
KW - HIV Infections
KW - Humans
KW - Male
KW - Organophosphonates
KW - Oxazines
KW - Prospective Studies
U2 - 10.1007/s15010-014-0630-4
DO - 10.1007/s15010-014-0630-4
M3 - Journal article
C2 - 24902520
VL - 42
SP - 757
EP - 762
JO - Therapies
JF - Therapies
SN - 0300-8126
IS - 4
ER -
ID: 137311036