A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions

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Standard

A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions. / Rodrigues, Nelson B.; McIntyre, Roger S.; Lipsitz, Orly; Lee, Yena; Cha, Danielle S.; Shekotikhina, Margarita; Vinberg, Maj; Gill, Hartej; Subramaniapillai, Mehala; Kratiuk, Kevin; Lin, Kangguang; Ho, Roger; Mansur, Rodrigo B.; Rosenblat, Joshua D.

I: Journal of Affective Disorders, Bind 282, 2021, s. 160-164.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rodrigues, NB, McIntyre, RS, Lipsitz, O, Lee, Y, Cha, DS, Shekotikhina, M, Vinberg, M, Gill, H, Subramaniapillai, M, Kratiuk, K, Lin, K, Ho, R, Mansur, RB & Rosenblat, JD 2021, 'A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions', Journal of Affective Disorders, bind 282, s. 160-164. https://doi.org/10.1016/j.jad.2020.12.119

APA

Rodrigues, N. B., McIntyre, R. S., Lipsitz, O., Lee, Y., Cha, D. S., Shekotikhina, M., Vinberg, M., Gill, H., Subramaniapillai, M., Kratiuk, K., Lin, K., Ho, R., Mansur, R. B., & Rosenblat, J. D. (2021). A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions. Journal of Affective Disorders, 282, 160-164. https://doi.org/10.1016/j.jad.2020.12.119

Vancouver

Rodrigues NB, McIntyre RS, Lipsitz O, Lee Y, Cha DS, Shekotikhina M o.a. A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions. Journal of Affective Disorders. 2021;282:160-164. https://doi.org/10.1016/j.jad.2020.12.119

Author

Rodrigues, Nelson B. ; McIntyre, Roger S. ; Lipsitz, Orly ; Lee, Yena ; Cha, Danielle S. ; Shekotikhina, Margarita ; Vinberg, Maj ; Gill, Hartej ; Subramaniapillai, Mehala ; Kratiuk, Kevin ; Lin, Kangguang ; Ho, Roger ; Mansur, Rodrigo B. ; Rosenblat, Joshua D. / A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions. I: Journal of Affective Disorders. 2021 ; Bind 282. s. 160-164.

Bibtex

@article{ad81624f9ea740169c55870c84916bb1,

title = "A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions",

abstract = "Background: Dissociation is a treatment-emergent adverse event commonly associated with IV ketamine, often measured using the 23-item Clinician-Administered Dissociative States Scale (CADSS). The objective of this study was to develop a short form version of the CADSS for easier clinical use. Methods: Retrospective data of 260 patients with treatment-resistant depression (TRD) receiving IV ketamine were randomly divided into two datasets. The first dataset (n = 130) was leveraged to develop a brief 6-item version of the CADSS (CADSS-6) based on items most sensitive to ketamine-induced dissociation. The CADSS-6 questions were then applied to the second dataset (n = 130) and the Spearman's correlation between the full-length CADSS and the CADSS-6 were assessed. Results: The CADSS-6 was developed from questions 1, 2, 6, 7, 15, and 22 from the full length CADSS. There was a strong significant correlation between the CADSS-6 total score and the CADSS total score at infusions 1 (rs(106) = 0.92, p < 0.001), 2 (rs(100) = 0.91, p < 0.001), 3(rs(99) = 0.95, p < 0.001) and 4 (rs(102) = 0.94, p < 0.001). Limitations: The CADSS-6 was developed using a retrospective data; therefore, the scale remains unvalidated in this population. Conclusions: The CADSS-6 presented herein was sensitive to dissociation experienced by patients receiving IV ketamine. Overall, the CADSS-6 was strongly correlated at each infusion with the full-length CADSS. While future studies should look to validate the CADSS-6 in a TRD sample, this scale offers clinicians a brief assessment that can be used to characterize symptoms of dissociation.",

keywords = "Bipolar disorder, Dissociation, Ketamine, Major depressive disorder, Treatment-resistant depression",

author = "Rodrigues, {Nelson B.} and McIntyre, {Roger S.} and Orly Lipsitz and Yena Lee and Cha, {Danielle S.} and Margarita Shekotikhina and Maj Vinberg and Hartej Gill and Mehala Subramaniapillai and Kevin Kratiuk and Kangguang Lin and Roger Ho and Mansur, {Rodrigo B.} and Rosenblat, {Joshua D.}",

year = "2021",

doi = "10.1016/j.jad.2020.12.119",

language = "English",

volume = "282",

pages = "160--164",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - A simplified 6-Item clinician administered dissociative symptom scale (CADSS-6) for monitoring dissociative effects of sub-anesthetic ketamine infusions

AU - Rodrigues, Nelson B.

AU - McIntyre, Roger S.

AU - Lipsitz, Orly

AU - Lee, Yena

AU - Cha, Danielle S.

AU - Shekotikhina, Margarita

AU - Vinberg, Maj

AU - Gill, Hartej

AU - Subramaniapillai, Mehala

AU - Kratiuk, Kevin

AU - Lin, Kangguang

AU - Ho, Roger

AU - Mansur, Rodrigo B.

AU - Rosenblat, Joshua D.

PY - 2021

Y1 - 2021

N2 - Background: Dissociation is a treatment-emergent adverse event commonly associated with IV ketamine, often measured using the 23-item Clinician-Administered Dissociative States Scale (CADSS). The objective of this study was to develop a short form version of the CADSS for easier clinical use. Methods: Retrospective data of 260 patients with treatment-resistant depression (TRD) receiving IV ketamine were randomly divided into two datasets. The first dataset (n = 130) was leveraged to develop a brief 6-item version of the CADSS (CADSS-6) based on items most sensitive to ketamine-induced dissociation. The CADSS-6 questions were then applied to the second dataset (n = 130) and the Spearman's correlation between the full-length CADSS and the CADSS-6 were assessed. Results: The CADSS-6 was developed from questions 1, 2, 6, 7, 15, and 22 from the full length CADSS. There was a strong significant correlation between the CADSS-6 total score and the CADSS total score at infusions 1 (rs(106) = 0.92, p < 0.001), 2 (rs(100) = 0.91, p < 0.001), 3(rs(99) = 0.95, p < 0.001) and 4 (rs(102) = 0.94, p < 0.001). Limitations: The CADSS-6 was developed using a retrospective data; therefore, the scale remains unvalidated in this population. Conclusions: The CADSS-6 presented herein was sensitive to dissociation experienced by patients receiving IV ketamine. Overall, the CADSS-6 was strongly correlated at each infusion with the full-length CADSS. While future studies should look to validate the CADSS-6 in a TRD sample, this scale offers clinicians a brief assessment that can be used to characterize symptoms of dissociation.

AB - Background: Dissociation is a treatment-emergent adverse event commonly associated with IV ketamine, often measured using the 23-item Clinician-Administered Dissociative States Scale (CADSS). The objective of this study was to develop a short form version of the CADSS for easier clinical use. Methods: Retrospective data of 260 patients with treatment-resistant depression (TRD) receiving IV ketamine were randomly divided into two datasets. The first dataset (n = 130) was leveraged to develop a brief 6-item version of the CADSS (CADSS-6) based on items most sensitive to ketamine-induced dissociation. The CADSS-6 questions were then applied to the second dataset (n = 130) and the Spearman's correlation between the full-length CADSS and the CADSS-6 were assessed. Results: The CADSS-6 was developed from questions 1, 2, 6, 7, 15, and 22 from the full length CADSS. There was a strong significant correlation between the CADSS-6 total score and the CADSS total score at infusions 1 (rs(106) = 0.92, p < 0.001), 2 (rs(100) = 0.91, p < 0.001), 3(rs(99) = 0.95, p < 0.001) and 4 (rs(102) = 0.94, p < 0.001). Limitations: The CADSS-6 was developed using a retrospective data; therefore, the scale remains unvalidated in this population. Conclusions: The CADSS-6 presented herein was sensitive to dissociation experienced by patients receiving IV ketamine. Overall, the CADSS-6 was strongly correlated at each infusion with the full-length CADSS. While future studies should look to validate the CADSS-6 in a TRD sample, this scale offers clinicians a brief assessment that can be used to characterize symptoms of dissociation.

KW - Bipolar disorder

KW - Dissociation

KW - Ketamine

KW - Major depressive disorder

KW - Treatment-resistant depression

U2 - 10.1016/j.jad.2020.12.119

DO - 10.1016/j.jad.2020.12.119

M3 - Journal article

C2 - 33418362

AN - SCOPUS:85098960065

VL - 282

SP - 160

EP - 164

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 255352081