A simple method to ensure homogeneous drug distribution during intrarenal infusion
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
A simple method to ensure homogeneous drug distribution during intrarenal infusion. / Postnov, Dmitry D; Salomonsson, Max; Sorensen, Charlotte M; Sosnovtseva, Olga V.
I: American Journal of Physiology: Renal Physiology, Bind 312, Nr. 3, 09.03.2017, s. F543-F548.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A simple method to ensure homogeneous drug distribution during intrarenal infusion
AU - Postnov, Dmitry D
AU - Salomonsson, Max
AU - Sorensen, Charlotte M
AU - Sosnovtseva, Olga V
N1 - Copyright © 2016, American Journal of Physiology-Renal Physiology.
PY - 2017/3/9
Y1 - 2017/3/9
N2 - Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method we use laser speckle imaging and renal artery flowmetry. The results show that, compared to the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.
AB - Intrarenal drug infusion plays an important role in renal experimental research. Laminar flow of the blood can cause streaming and inhomogeneous intrarenal distribution of infused drugs. We suggest a simple method to achieve a homogeneous intravascular distribution of drugs infused into the renal artery of anesthetized rats. The method employs a multiple sidehole catheter inserted into the renal artery, which enables an efficient drug mixing with the arterial blood. To verify the efficiency of this method we use laser speckle imaging and renal artery flowmetry. The results show that, compared to the conventional single-hole catheter, the multiple sidehole catheter provides a more uniform drug distribution and a homogenous vascular response on the surface of the kidney.
U2 - 10.1152/ajprenal.00417.2016
DO - 10.1152/ajprenal.00417.2016
M3 - Journal article
C2 - 27881397
VL - 312
SP - F543-F548
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
SN - 1931-857X
IS - 3
ER -
ID: 169641381