A Primer on Concepts and Applications of Proteomics in Neuroscience
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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A Primer on Concepts and Applications of Proteomics in Neuroscience. / Hosp, Fabian; Mann, Matthias.
I: Neuron, Bind 96, Nr. 3, 01.11.2017, s. 558-571.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - A Primer on Concepts and Applications of Proteomics in Neuroscience
AU - Hosp, Fabian
AU - Mann, Matthias
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful "omic" technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational modifications. We also discuss how advanced workflows help to unravel spatial, regulatory, and temporal aspects of neuronal systems. These tools and approaches have already led to detailed and quantitative proteomic maps of the brain and its signaling architecture, generating new insights into health and disease. We predict that these new approaches will also accelerate biomarker discovery and contribute to novel therapeutics for neurodegenerative and other brain-related diseases.
AB - The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful "omic" technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational modifications. We also discuss how advanced workflows help to unravel spatial, regulatory, and temporal aspects of neuronal systems. These tools and approaches have already led to detailed and quantitative proteomic maps of the brain and its signaling architecture, generating new insights into health and disease. We predict that these new approaches will also accelerate biomarker discovery and contribute to novel therapeutics for neurodegenerative and other brain-related diseases.
KW - Animals
KW - Brain
KW - Chromatography, Liquid
KW - Humans
KW - Mass Spectrometry
KW - Neurons
KW - Neurosciences
KW - Proteomics
KW - Journal Article
KW - Review
U2 - 10.1016/j.neuron.2017.09.025
DO - 10.1016/j.neuron.2017.09.025
M3 - Review
C2 - 29096073
VL - 96
SP - 558
EP - 571
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 3
ER -
ID: 186184545