TY - JOUR

T1 - A longitudinal evaluation of hearing and ventilation tube insertion in patients with primary ciliary dyskinesia

AU - Andersen, Tobias Nicolai

AU - Alanin, Mikkel Christian

AU - von Buchwald, Christian

AU - Nielsen, Lars Holme

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/10

Y1 - 2016/10

N2 - INTRODUCTION: Primary ciliary dyskinesia (PCD) is an autosomal recessive genetic disease, which primarily manifests with oto-sino-pulmonary symptoms. Otitis media with effusion (OME) is common from early childhood. The existing literature on OME management in PCD is conflicting. The goals of the present study were firstly to evaluate the long-term hearing in PCD patients and secondly to determine the influence of ventilation tube (VT) insertion on hearing and postoperative otorrhoea.METHODS: A longitudinal retrospective study extracting the hearing level (pure tone average (0.5, 1, 2, 4 kHz, PTA)) and tympanometry from the medical records. Furthermore, the patient files were reviewed for VT insertion and postoperative otorrhoea. Postoperative otorrhoea was defined prolonged when it lasted for four weeks or longer.RESULTS: Fifty-seven patients were identified in a 30-year period, age 2-72 years, and 278 audiometries were evaluated. The median number of audiometries per patient was 3 (range 1-29) and the median follow-up was 60 months (range 0-351 months). The mean PTA was 34 dB HL in patients below six years of age and improved significantly (p < 0.0001) with age. VT insertion improved hearing; however, 48% of patients with VT insertion experienced prolonged otorrhoea.CONCLUSION: In this study of PCD patients the hearing improved as a function of age as well as following VT insertion. However, VT insertion was also associated with prolonged otorrhoea.

AB - INTRODUCTION: Primary ciliary dyskinesia (PCD) is an autosomal recessive genetic disease, which primarily manifests with oto-sino-pulmonary symptoms. Otitis media with effusion (OME) is common from early childhood. The existing literature on OME management in PCD is conflicting. The goals of the present study were firstly to evaluate the long-term hearing in PCD patients and secondly to determine the influence of ventilation tube (VT) insertion on hearing and postoperative otorrhoea.METHODS: A longitudinal retrospective study extracting the hearing level (pure tone average (0.5, 1, 2, 4 kHz, PTA)) and tympanometry from the medical records. Furthermore, the patient files were reviewed for VT insertion and postoperative otorrhoea. Postoperative otorrhoea was defined prolonged when it lasted for four weeks or longer.RESULTS: Fifty-seven patients were identified in a 30-year period, age 2-72 years, and 278 audiometries were evaluated. The median number of audiometries per patient was 3 (range 1-29) and the median follow-up was 60 months (range 0-351 months). The mean PTA was 34 dB HL in patients below six years of age and improved significantly (p < 0.0001) with age. VT insertion improved hearing; however, 48% of patients with VT insertion experienced prolonged otorrhoea.CONCLUSION: In this study of PCD patients the hearing improved as a function of age as well as following VT insertion. However, VT insertion was also associated with prolonged otorrhoea.

KW - Acoustic Impedance Tests

KW - Adolescent

KW - Adult

KW - Aged

KW - Audiometry

KW - Child

KW - Child, Preschool

KW - Female

KW - Follow-Up Studies

KW - Hearing

KW - Humans

KW - Kartagener Syndrome

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Middle Ear Ventilation

KW - Otitis Media with Effusion

KW - Postoperative Complications

KW - Retrospective Studies

KW - Treatment Outcome

KW - Young Adult

KW - Journal Article

KW - Observational Study

U2 - 10.1016/j.ijporl.2016.08.011

DO - 10.1016/j.ijporl.2016.08.011

M3 - Journal article

C2 - 27619050

VL - 89

SP - 164

EP - 168

JO - International Journal of Pediatric Otorhinolaryngology Extra

JF - International Journal of Pediatric Otorhinolaryngology Extra

SN - 1871-4048

ER -