A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System. / Beliveau, Vincent; Ganz-Benjaminsen, Melanie; Feng, Ling; Ozenne, Brice; Højgaard, Liselotte; Fisher, Patrick M.; Svarer, Claus; Greve, Douglas N.; Knudsen, Gitte M.

I: The Journal of Neuroscience, Bind 37, Nr. 1, 04.01.2017, s. 120-128.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Beliveau, V, Ganz-Benjaminsen, M, Feng, L, Ozenne, B, Højgaard, L, Fisher, PM, Svarer, C, Greve, DN & Knudsen, GM 2017, 'A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System', The Journal of Neuroscience, bind 37, nr. 1, s. 120-128. https://doi.org/10.1523/JNEUROSCI.2830-16.2017

APA

Beliveau, V., Ganz-Benjaminsen, M., Feng, L., Ozenne, B., Højgaard, L., Fisher, P. M., Svarer, C., Greve, D. N., & Knudsen, G. M. (2017). A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System. The Journal of Neuroscience, 37(1), 120-128. https://doi.org/10.1523/JNEUROSCI.2830-16.2017

Vancouver

Beliveau V, Ganz-Benjaminsen M, Feng L, Ozenne B, Højgaard L, Fisher PM o.a. A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System. The Journal of Neuroscience. 2017 jan 4;37(1):120-128. https://doi.org/10.1523/JNEUROSCI.2830-16.2017

Author

Beliveau, Vincent ; Ganz-Benjaminsen, Melanie ; Feng, Ling ; Ozenne, Brice ; Højgaard, Liselotte ; Fisher, Patrick M. ; Svarer, Claus ; Greve, Douglas N. ; Knudsen, Gitte M. / A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System. I: The Journal of Neuroscience. 2017 ; Bind 37, Nr. 1. s. 120-128.

Bibtex

@article{8c4ecbce37834fc0885d28e9b5748079,
title = "A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System",
abstract = "The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT). The atlas is created from molecular and structural high-resolution neuroimaging data consisting of positron emission tomography (PET) and magnetic resonance imaging (MRI) scans acquired in a total of 210 healthy individuals. Comparison of the regional PET binding measures with postmortem human brain autoradiography outcomes showed a high correlation for the five 5-HT targets and this enabled us to transform the atlas to represent protein densities (in picomoles per milliliter). We also assessed the regional association between protein concentration and mRNA expression in the human brain by comparing the 5-HT density across the atlas with data from the Allen Human Brain atlas and identified receptor- and transporter-specific associations that show the regional relation between the two measures. Together, these data provide unparalleled insight into the serotonin system of the human brain.SIGNIFICANCE STATEMENT We present a high-resolution positron emission tomography (PET)- and magnetic resonance imaging-based human brain atlas of important serotonin receptors and the transporter. The regional PET-derived binding measures correlate strongly with the corresponding autoradiography protein levels. The strong correlation enables the transformation of the PET-derived human brain atlas into a protein density map of the serotonin (5-hydroxytryptamine, 5-HT) system. Next, we compared the regional receptor/transporter protein densities with mRNA levels and uncovered unique associations between protein expression and density at high detail. This new in vivo neuroimaging atlas of the 5-HT system not only provides insight in the human brain's regional protein synthesis, transport, and density, but also represents a valuable source of information for the neuroscience community as a comparative instrument to assess brain disorders.",
keywords = "5-HT, atlas, autoradiography, MRI, mRNA, PET",
author = "Vincent Beliveau and Melanie Ganz-Benjaminsen and Ling Feng and Brice Ozenne and Liselotte H{\o}jgaard and Fisher, {Patrick M.} and Claus Svarer and Greve, {Douglas N.} and Knudsen, {Gitte M.}",
year = "2017",
month = jan,
day = "4",
doi = "10.1523/JNEUROSCI.2830-16.2017",
language = "English",
volume = "37",
pages = "120--128",
journal = "The Journal of neuroscience : the official journal of the Society for Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "1",

}

RIS

TY - JOUR

T1 - A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System

AU - Beliveau, Vincent

AU - Ganz-Benjaminsen, Melanie

AU - Feng, Ling

AU - Ozenne, Brice

AU - Højgaard, Liselotte

AU - Fisher, Patrick M.

AU - Svarer, Claus

AU - Greve, Douglas N.

AU - Knudsen, Gitte M.

PY - 2017/1/4

Y1 - 2017/1/4

N2 - The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT). The atlas is created from molecular and structural high-resolution neuroimaging data consisting of positron emission tomography (PET) and magnetic resonance imaging (MRI) scans acquired in a total of 210 healthy individuals. Comparison of the regional PET binding measures with postmortem human brain autoradiography outcomes showed a high correlation for the five 5-HT targets and this enabled us to transform the atlas to represent protein densities (in picomoles per milliliter). We also assessed the regional association between protein concentration and mRNA expression in the human brain by comparing the 5-HT density across the atlas with data from the Allen Human Brain atlas and identified receptor- and transporter-specific associations that show the regional relation between the two measures. Together, these data provide unparalleled insight into the serotonin system of the human brain.SIGNIFICANCE STATEMENT We present a high-resolution positron emission tomography (PET)- and magnetic resonance imaging-based human brain atlas of important serotonin receptors and the transporter. The regional PET-derived binding measures correlate strongly with the corresponding autoradiography protein levels. The strong correlation enables the transformation of the PET-derived human brain atlas into a protein density map of the serotonin (5-hydroxytryptamine, 5-HT) system. Next, we compared the regional receptor/transporter protein densities with mRNA levels and uncovered unique associations between protein expression and density at high detail. This new in vivo neuroimaging atlas of the 5-HT system not only provides insight in the human brain's regional protein synthesis, transport, and density, but also represents a valuable source of information for the neuroscience community as a comparative instrument to assess brain disorders.

AB - The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT). The atlas is created from molecular and structural high-resolution neuroimaging data consisting of positron emission tomography (PET) and magnetic resonance imaging (MRI) scans acquired in a total of 210 healthy individuals. Comparison of the regional PET binding measures with postmortem human brain autoradiography outcomes showed a high correlation for the five 5-HT targets and this enabled us to transform the atlas to represent protein densities (in picomoles per milliliter). We also assessed the regional association between protein concentration and mRNA expression in the human brain by comparing the 5-HT density across the atlas with data from the Allen Human Brain atlas and identified receptor- and transporter-specific associations that show the regional relation between the two measures. Together, these data provide unparalleled insight into the serotonin system of the human brain.SIGNIFICANCE STATEMENT We present a high-resolution positron emission tomography (PET)- and magnetic resonance imaging-based human brain atlas of important serotonin receptors and the transporter. The regional PET-derived binding measures correlate strongly with the corresponding autoradiography protein levels. The strong correlation enables the transformation of the PET-derived human brain atlas into a protein density map of the serotonin (5-hydroxytryptamine, 5-HT) system. Next, we compared the regional receptor/transporter protein densities with mRNA levels and uncovered unique associations between protein expression and density at high detail. This new in vivo neuroimaging atlas of the 5-HT system not only provides insight in the human brain's regional protein synthesis, transport, and density, but also represents a valuable source of information for the neuroscience community as a comparative instrument to assess brain disorders.

KW - 5-HT

KW - atlas

KW - autoradiography

KW - MRI

KW - mRNA

KW - PET

U2 - 10.1523/JNEUROSCI.2830-16.2017

DO - 10.1523/JNEUROSCI.2830-16.2017

M3 - Journal article

C2 - 28053035

VL - 37

SP - 120

EP - 128

JO - The Journal of neuroscience : the official journal of the Society for Neuroscience

JF - The Journal of neuroscience : the official journal of the Society for Neuroscience

SN - 0270-6474

IS - 1

ER -

ID: 172640604