A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients. / Fahnøe, Ulrik; Ronit, Andreas; Berg, Ronan M G; Jørgensen, Sofie E; Mogensen, Trine H; Underwood, Alexander P; Scheel, Troels K H; Bukh, Jens; Plovsing, Ronni R.

I: The Journal of Infectious Diseases, Bind 226, Nr. 12, 2022, s. 2137–2141.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Fahnøe, U, Ronit, A, Berg, RMG, Jørgensen, SE, Mogensen, TH, Underwood, AP, Scheel, TKH, Bukh, J & Plovsing, RR 2022, 'A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients', The Journal of Infectious Diseases, bind 226, nr. 12, s. 2137–2141. https://doi.org/10.1093/infdis/jiac218

APA

Fahnøe, U., Ronit, A., Berg, R. M. G., Jørgensen, S. E., Mogensen, T. H., Underwood, A. P., Scheel, T. K. H., Bukh, J., & Plovsing, R. R. (2022). A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients. The Journal of Infectious Diseases, 226(12), 2137–2141. https://doi.org/10.1093/infdis/jiac218

Vancouver

Fahnøe U, Ronit A, Berg RMG, Jørgensen SE, Mogensen TH, Underwood AP o.a. A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients. The Journal of Infectious Diseases. 2022;226(12):2137–2141. https://doi.org/10.1093/infdis/jiac218

Author

Fahnøe, Ulrik ; Ronit, Andreas ; Berg, Ronan M G ; Jørgensen, Sofie E ; Mogensen, Trine H ; Underwood, Alexander P ; Scheel, Troels K H ; Bukh, Jens ; Plovsing, Ronni R. / A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients. I: The Journal of Infectious Diseases. 2022 ; Bind 226, Nr. 12. s. 2137–2141.

Bibtex

@article{81ba7e3a613d41a08f0d19e1b0c18e30,
title = "A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients",
abstract = "The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19 associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (DXM+ or DXM-) and 8 non-COVID-19 critically ill controls. CARDS (+DXM) was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis and FC-gamma receptor signalling. Most ISGs were upregulated in CARDS, particularly in CARDS (-DXM). In conclusion, DXM treatment was not associated with regulation of pro-inflammatory pathways in CARDS but with regulation of other local immune responses.",
author = "Ulrik Fahn{\o}e and Andreas Ronit and Berg, {Ronan M G} and J{\o}rgensen, {Sofie E} and Mogensen, {Trine H} and Underwood, {Alexander P} and Scheel, {Troels K H} and Jens Bukh and Plovsing, {Ronni R}",
note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America and HIV Medicine Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2022",
doi = "10.1093/infdis/jiac218",
language = "English",
volume = "226",
pages = "2137–2141",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "12",

}

RIS

TY - JOUR

T1 - A distinct dexamethasone-dependent gene expression profile in the lungs of COVID-19 patients

AU - Fahnøe, Ulrik

AU - Ronit, Andreas

AU - Berg, Ronan M G

AU - Jørgensen, Sofie E

AU - Mogensen, Trine H

AU - Underwood, Alexander P

AU - Scheel, Troels K H

AU - Bukh, Jens

AU - Plovsing, Ronni R

N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America and HIV Medicine Association. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19 associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (DXM+ or DXM-) and 8 non-COVID-19 critically ill controls. CARDS (+DXM) was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis and FC-gamma receptor signalling. Most ISGs were upregulated in CARDS, particularly in CARDS (-DXM). In conclusion, DXM treatment was not associated with regulation of pro-inflammatory pathways in CARDS but with regulation of other local immune responses.

AB - The effects of dexamethasone (DXM) treatment on pulmonary immunity in COVID-19 associated acute respiratory distress syndrome (CARDS) remain insufficiently understood. We performed transcriptomic RNA-seq analysis of bronchoalveolar lavage fluid from 20 mechanically ventilated patients: 12 with CARDS (DXM+ or DXM-) and 8 non-COVID-19 critically ill controls. CARDS (+DXM) was characterized by upregulation of genes related to B-cell and complement pathway activation, antigen presentation, phagocytosis and FC-gamma receptor signalling. Most ISGs were upregulated in CARDS, particularly in CARDS (-DXM). In conclusion, DXM treatment was not associated with regulation of pro-inflammatory pathways in CARDS but with regulation of other local immune responses.

U2 - 10.1093/infdis/jiac218

DO - 10.1093/infdis/jiac218

M3 - Journal article

C2 - 35639922

VL - 226

SP - 2137

EP - 2141

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 12

ER -

ID: 308832711