A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened

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Standard

A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened. / Stasiulewicz, Magdalena; Gray, Shona; Mastromina, Ioanna; Silva, Joana Clara; Bjorklund, Mia; Seymour, Philip A; Booth, David; Thompson, Calum; Green, Rich; Hall, Emma A; Serup, Palle; Dale, J Kim.

I: Development, Bind 142, 2015, s. 2291-2303.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Stasiulewicz, M, Gray, S, Mastromina, I, Silva, JC, Bjorklund, M, Seymour, PA, Booth, D, Thompson, C, Green, R, Hall, EA, Serup, P & Dale, JK 2015, 'A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened', Development, bind 142, s. 2291-2303. https://doi.org/10.1242/dev.125237

APA

Stasiulewicz, M., Gray, S., Mastromina, I., Silva, J. C., Bjorklund, M., Seymour, P. A., Booth, D., Thompson, C., Green, R., Hall, E. A., Serup, P., & Dale, J. K. (2015). A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened. Development, 142, 2291-2303. https://doi.org/10.1242/dev.125237

Vancouver

Stasiulewicz M, Gray S, Mastromina I, Silva JC, Bjorklund M, Seymour PA o.a. A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened. Development. 2015;142:2291-2303. https://doi.org/10.1242/dev.125237

Author

Stasiulewicz, Magdalena ; Gray, Shona ; Mastromina, Ioanna ; Silva, Joana Clara ; Bjorklund, Mia ; Seymour, Philip A ; Booth, David ; Thompson, Calum ; Green, Rich ; Hall, Emma A ; Serup, Palle ; Dale, J Kim. / A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened. I: Development. 2015 ; Bind 142. s. 2291-2303.

Bibtex

@article{5ce08e4d272c4109b66d2dc47e187df0,
title = "A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened",
abstract = "Notochord-derived Sonic Hedgehog (SHH) is essential for dorso-ventral patterning of the overlying neural tube. Increasing concentration and duration of Shh signal induces progenitors to acquire progressively more ventral fates. We show Notch signalling augments the response of neuroepithelial cells to Shh, leading to the induction of higher expression levels of the Shh target gene Ptc1 and subsequently induction of more ventral cell fates. Furthermore, we demonstrate activated Notch1 leads to pronounced accumulation of Smo within primary cilia and elevated levels of full-length Gli3. Finally, we show Notch activity promotes longer primary cilia both in vitro and in vivo. Strikingly, these Notch-regulated effects are Shh-independent. These data identify Notch signalling as a novel modulator of Shh signalling which acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.",
author = "Magdalena Stasiulewicz and Shona Gray and Ioanna Mastromina and Silva, {Joana Clara} and Mia Bjorklund and Seymour, {Philip A} and David Booth and Calum Thompson and Rich Green and Hall, {Emma A} and Palle Serup and Dale, {J Kim}",
note = "{\textcopyright} 2015. Published by The Company of Biologists Ltd.",
year = "2015",
doi = "10.1242/dev.125237",
language = "English",
volume = "142",
pages = "2291--2303",
journal = "Development",
issn = "0950-1991",
publisher = "The Company of Biologists",

}

RIS

TY - JOUR

T1 - A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened

AU - Stasiulewicz, Magdalena

AU - Gray, Shona

AU - Mastromina, Ioanna

AU - Silva, Joana Clara

AU - Bjorklund, Mia

AU - Seymour, Philip A

AU - Booth, David

AU - Thompson, Calum

AU - Green, Rich

AU - Hall, Emma A

AU - Serup, Palle

AU - Dale, J Kim

N1 - © 2015. Published by The Company of Biologists Ltd.

PY - 2015

Y1 - 2015

N2 - Notochord-derived Sonic Hedgehog (SHH) is essential for dorso-ventral patterning of the overlying neural tube. Increasing concentration and duration of Shh signal induces progenitors to acquire progressively more ventral fates. We show Notch signalling augments the response of neuroepithelial cells to Shh, leading to the induction of higher expression levels of the Shh target gene Ptc1 and subsequently induction of more ventral cell fates. Furthermore, we demonstrate activated Notch1 leads to pronounced accumulation of Smo within primary cilia and elevated levels of full-length Gli3. Finally, we show Notch activity promotes longer primary cilia both in vitro and in vivo. Strikingly, these Notch-regulated effects are Shh-independent. These data identify Notch signalling as a novel modulator of Shh signalling which acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.

AB - Notochord-derived Sonic Hedgehog (SHH) is essential for dorso-ventral patterning of the overlying neural tube. Increasing concentration and duration of Shh signal induces progenitors to acquire progressively more ventral fates. We show Notch signalling augments the response of neuroepithelial cells to Shh, leading to the induction of higher expression levels of the Shh target gene Ptc1 and subsequently induction of more ventral cell fates. Furthermore, we demonstrate activated Notch1 leads to pronounced accumulation of Smo within primary cilia and elevated levels of full-length Gli3. Finally, we show Notch activity promotes longer primary cilia both in vitro and in vivo. Strikingly, these Notch-regulated effects are Shh-independent. These data identify Notch signalling as a novel modulator of Shh signalling which acts mechanistically via regulation of ciliary localisation of key components of its transduction machinery.

U2 - 10.1242/dev.125237

DO - 10.1242/dev.125237

M3 - Journal article

C2 - 25995356

VL - 142

SP - 2291

EP - 2303

JO - Development

JF - Development

SN - 0950-1991

ER -

ID: 141322451