A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

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A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. / Jespersen, Naja Zenius; Larsen, Therese Juhlin; Peijs, Lone; Daugaard, Søren; Homøe, Preben; Loft, Annika; de Jong, Jasper; Mathur, Neha; Cannon, Barbara; Nedergaard, Jan; Pedersen, Bente Klarlund; Møller, Kirsten; Schéele, Camilla Charlotte.

I: Cell Metabolism, Bind 17, Nr. 5, 07.05.2013, s. 798-805.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jespersen, NZ, Larsen, TJ, Peijs, L, Daugaard, S, Homøe, P, Loft, A, de Jong, J, Mathur, N, Cannon, B, Nedergaard, J, Pedersen, BK, Møller, K & Schéele, CC 2013, 'A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans', Cell Metabolism, bind 17, nr. 5, s. 798-805. https://doi.org/10.1016/j.cmet.2013.04.011

APA

Jespersen, N. Z., Larsen, T. J., Peijs, L., Daugaard, S., Homøe, P., Loft, A., de Jong, J., Mathur, N., Cannon, B., Nedergaard, J., Pedersen, B. K., Møller, K., & Schéele, C. C. (2013). A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metabolism, 17(5), 798-805. https://doi.org/10.1016/j.cmet.2013.04.011

Vancouver

Jespersen NZ, Larsen TJ, Peijs L, Daugaard S, Homøe P, Loft A o.a. A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. Cell Metabolism. 2013 maj 7;17(5):798-805. https://doi.org/10.1016/j.cmet.2013.04.011

Author

Jespersen, Naja Zenius ; Larsen, Therese Juhlin ; Peijs, Lone ; Daugaard, Søren ; Homøe, Preben ; Loft, Annika ; de Jong, Jasper ; Mathur, Neha ; Cannon, Barbara ; Nedergaard, Jan ; Pedersen, Bente Klarlund ; Møller, Kirsten ; Schéele, Camilla Charlotte. / A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. I: Cell Metabolism. 2013 ; Bind 17, Nr. 5. s. 798-805.

Bibtex

@article{c6cac36722204d7a82e4f3a98d500b2c,

title = "A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans",

abstract = "Human brown adipose tissue (BAT) has been detected in adults but was recently suggested to be of brite/beige origin. We collected BAT from the supraclavicular region in 21 patients undergoing surgery for suspected cancer in the neck area and assessed the gene expression of established murine markers for brown, brite/beige, and white adipocytes. We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26. A similar mRNA expression profile was observed when comparing isolated human adipocytes from BAT and white adipose tissue (WAT) depots, differentiated in vitro. In conclusion, our data suggest that human BAT might consist of both classical brown and recruitable brite adipocytes, an observation important for future considerations on how to induce human BAT.",

author = "Jespersen, {Naja Zenius} and Larsen, {Therese Juhlin} and Lone Peijs and S{\o}ren Daugaard and Preben Hom{\o}e and Annika Loft and {de Jong}, Jasper and Neha Mathur and Barbara Cannon and Jan Nedergaard and Pedersen, {Bente Klarlund} and Kirsten M{\o}ller and Sch{\'e}ele, {Camilla Charlotte}",

year = "2013",

month = may,

day = "7",

doi = "10.1016/j.cmet.2013.04.011",

language = "English",

volume = "17",

pages = "798--805",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "5",

}

RIS

TY - JOUR

T1 - A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans

AU - Jespersen, Naja Zenius

AU - Larsen, Therese Juhlin

AU - Peijs, Lone

AU - Daugaard, Søren

AU - Homøe, Preben

AU - Loft, Annika

AU - de Jong, Jasper

AU - Mathur, Neha

AU - Cannon, Barbara

AU - Nedergaard, Jan

AU - Pedersen, Bente Klarlund

AU - Møller, Kirsten

AU - Schéele, Camilla Charlotte

PY - 2013/5/7

Y1 - 2013/5/7

N2 - Human brown adipose tissue (BAT) has been detected in adults but was recently suggested to be of brite/beige origin. We collected BAT from the supraclavicular region in 21 patients undergoing surgery for suspected cancer in the neck area and assessed the gene expression of established murine markers for brown, brite/beige, and white adipocytes. We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26. A similar mRNA expression profile was observed when comparing isolated human adipocytes from BAT and white adipose tissue (WAT) depots, differentiated in vitro. In conclusion, our data suggest that human BAT might consist of both classical brown and recruitable brite adipocytes, an observation important for future considerations on how to induce human BAT.

AB - Human brown adipose tissue (BAT) has been detected in adults but was recently suggested to be of brite/beige origin. We collected BAT from the supraclavicular region in 21 patients undergoing surgery for suspected cancer in the neck area and assessed the gene expression of established murine markers for brown, brite/beige, and white adipocytes. We demonstrate that a classical brown expression signature, including upregulation of miR-206, miR-133b, LHX8, and ZIC1 and downregulation of HOXC8 and HOXC9, coexists with an upregulation of two newly established brite/beige markers, TBX1 and TMEM26. A similar mRNA expression profile was observed when comparing isolated human adipocytes from BAT and white adipose tissue (WAT) depots, differentiated in vitro. In conclusion, our data suggest that human BAT might consist of both classical brown and recruitable brite adipocytes, an observation important for future considerations on how to induce human BAT.

U2 - 10.1016/j.cmet.2013.04.011

DO - 10.1016/j.cmet.2013.04.011

M3 - Journal article

C2 - 23663743

VL - 17

SP - 798

EP - 805

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 5

ER -

ID: 48465067