[18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice

[18F]FLT PET for Non-Invasive Assessment of Tumor Sensitivity to Chemotherapy: Studies with Experimental Chemotherapy TP202377 in Human Cancer Xenografts in Mice: studies with experimental chemotherapy TP202377 in human cancer xenografts in mice

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Wessel, Mette Munk
Kamille Dumong Erichsen
Björkling, Fredrik
J Madsen
Peter B Jensen
Maxwell Sehested
Højgaard, Liselotte
Kjær, Andreas

3'-deoxy-3'-[¹⁸F]fluorothymidine ([18F]FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use [18F]FLT positron emission tomography (PET) to study non-invasively early anti-proliferative effects of the experimental chemotherapeutic agent TP202377 in both sensitive and resistant tumors.

Originalsprog	Engelsk
Artikelnummer	e50618
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	11
Sider (fra-til)	e50618
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0050618
Status	Udgivet - 2012

ID: 45864200