Trine Meldgaard Lund

Trine Meldgaard Lund

Lektor

  • Translational Pharmacology

    22, Bygning: 1-115

    2100 København Ø

    Telefon: +45 35 33 63 40

Primære forskningsområder

Population PKPD modelling

Aktuel forskning

Pharmacometrics

We optimise pharmacotherapy and clinical trial designs by characterising pharmacokinetic-pharmacodynamic relationships using mathematical models that identify sources of variability in drug response.

Examples of projects in our group:

•Fixed dose combinations in drug development - Design of Trials for Identifying Optimal Combination Ratios using Advanced Computer Modelling Tools
•Model-based dose finding in clinical drug development
•The development of fixed-dose combinations (FDCs) through improved methodology – regulatory perspective
•Linking rescue medication with pain intensity using PKPD modelling in clinical pain trials
•PK meta-model on morphine and active metabolite based on 22 clinical studies
•PKPD modelling on synergistic effects of gabapentin and morphine
•Modelling on effect of high-dose target-controlled naloxone infusion on pain and hyperalgesia in patients following groin-hernia-repair
•Differences in metabolic activity of CYP enzymes in obese and lean children

 

Undervisnings- og vejledningsområder

Pharmacokinetics and Pharmacodynamics on the following courses:

Basic pharmacology, Principles of Pharmacology, Organ-related pharmacology

Elective course in Pharmacokinetics and -dynamics and post graduate MIND courses and PhD course

ID: 1303792