Kristian Almstrup
Lektor
Medical Genetics Program
Blegdamsvej 3, 2200 København N.
The Almstrup group is mainly located at the Department of Growth and Reproduction, at Copenhagen University Hospital - Rigshospitalet but is also affiliated with the Department of Cellular and Molecular Medicine, at University of Copenhagen. Our research focus on studies that connect genetic and epigenetic variation to reproductive endpoints, testicular gene expression and functional studies of sperm cells.
Group homepage: https://www.rigshospitalet.dk/almstrup
Primære forskningsområder
Genetic and epigenetic variation in relation to reproductive endpoints, testicular gene expression and functional studies of sperm cells.
Undervisnings- og vejledningsområder
Medical genetics course (Medicine and Molecular Biomedicine)
PhD course in Genetics of Reproduction, May 16-17, 2022
Graduate programmes: Life Cycle in Medicine and Cellular & Genetic Medicine
Mulige interessekonflikter
None
Aktuel forskning
Genetic and epigenetic variation
The Almstrup group has been pioneering in describing genetic and epigenetic variation associated with several reproductive endpoints. This includes genetic variants causing non-obstructive azoospermia (GEMINI, IMIGC consortia), genetic variants associated with testicular germ cell cancer (TECAC consortia) as well as genetic variants and DNA methylation patterns that have a significant effect on the age of pubertal onset.
Small RNAs
Small RNAs, like micro RNAs (miRNAs) and the PIWI-interacting RNAs (piRNAs), is an area of great interest to our group. We have shown that the piRNAs, which are nearly unique to male germ cell, are essential for human spermatogenesis and have identified piRNAs in seminal plasma and in circulation that may serve as markers of testicular function. However, also specific miRNAs show great promise as novel sensitive biomarker of testicular germ cell cancer.
Testicular gene expression
The testis is a complex tissue with many different cell types and studies of testicular gene expression, therefore, needs to take into account the composition of cell types that are present in the analysis. The Almstrup group has been involved in studies of testicular gene expression since the pre-omics era, using differential display techniques, and are now working with single-cell/nuclei methods and spatial transcriptomics.
Sperm cell function
Sperm cells are unique because they have a tightly packed haploid genome, are extremely differentiated, and has the sole purpose of fertilising an egg. We have shown that the number of viable sperm cells with an intact acrosome is important for the fertility of men and that environmental chemicals can influence sperm cell function directly.
Udvalgte publikationer
- Udgivet
Variant PNLDC1, Defective piRNA Processing, and Azoospermia
Nagirnaja, L., Mørup, N., Nielsen, J. E., Stakaitis, R., Golubickaite, I., Oud, M. S., Winge, S. B., Carvalho, F., Aston, K. I., Khani, F., Van Der Heijden, G. W., Marques, C. J., Skakkebæk, Niels Erik, Rajpert–de Meyts, E., Schlegel, P. N., Jørgensen, N., Veltman, J. A., Lopes, A. M., Conrad, D. F. & Almstrup, Kristian, 19 aug. 2021, I: New England Journal of Medicine. 385, 8, s. 707-719 13 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
- Udgivet
PIWI ‐interacting RNAs and human testicular function
Saritas, G., Main, A. M., Winge, S. B., Mørup, N. & Almstrup, Kristian, 2022, I: WIREs Mechanisms of Disease. 14, 6, e1572.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Diverse monogenic subforms of human spermatogenic failure
Nagirnaja, L., Lopes, A. M., Charng, W., Miller, B., Stakaitis, R., Golubickaite, I., Stendahl, A., Luan, T., Friedrich, C., Mahyari, E., Fadial, E., Kasak, L., Vigh-Conrad, K., Oud, M. S., Xavier, M. J., Cheers, S. R., James, E. R., Guo, J., Jenkins, T. G., Riera-Escamilla, A., Barros, A., Carvalho, F., Fernandes, S., Gonçalves, J., Gurnett, C. A., Jørgensen, N., Jezek, D., Jungheim, E. S., Kliesch, S., McLachlan, R. I., Omurtag, K. R., Pilatz, A., Sandlow, J. I., Smith, J., Eisenberg, M. L., Hotaling, J. M., Jarvi, K. A., Punab, M., Rajpert-De Meyts, E., Carrell, D. T., Krausz, C., Laan, M., O'Bryan, M. K., Schlegel, P. N., Tüttelmann, F., Veltman, J. A., Almstrup, Kristian, Aston, K. I. & Conrad, D. F., 26 dec. 2022, I: Nature Communications. 13, 1, s. 7953Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
- Udgivet
The molecular evolution of spermatogenesis across mammals
Murat, F., Mbengue, N., Winge, S. B., Trefzer, T., Leushkin, E., Sepp, M., Cardoso-Moreira, M., Schmidt, J., Schneider, C., Mößinger, K., Brüning, T., Lamanna, F., Belles, M. R., Conrad, C., Kondova, I., Bontrop, R., Behr, R., Khaitovich, P., Pääbo, S., Marques-Bonet, T., Grützner, F., Almstrup, Kristian, Schierup, M. H. & Kaessmann, H., 2023, I: Nature. 613, s. 308–316Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
- Udgivet
Environmental factors in declining human fertility
Skakkebæk, Niels Erik, Lindahl-Jacobsen, R., Levine, H., Andersson, A., Jørgensen, N., Main, Katharina Maria, Lidegaard, Øjvind, Priskorn, Lærke, Holmboe, S. A., Bräuner, E. V., Almstrup, Kristian, Franca, L. R., Znaor, A., Kortenkamp, A., Hart, R. J. & Juul, Anders, 2022, I: Nature Reviews Endocrinology. 18, s. 139–157Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
- Udgivet
Identification of 22 susceptibility loci associated with testicular germ cell tumors
Pluta, J. & The Testicular Cancer Consortium, T. T. C. C., 2021, I: Nature Communications. 12, 1, 4487.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours
Almstrup, Kristian, Lobo, J., Mørup, N., Belge, G., Rajpert-De Meyts, E., Looijenga, L. H. J. & Dieckmann, K. P., 1 apr. 2020, I: Nature Reviews Urology. 17, 4, s. 201-213 13 s.Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
Udvalgte aktiviteter
Andrology (Tidsskrift)
Almstrup, Kristian (Redaktør)
1 jan. 2023Aktivitet: Peer-review og redaktionelt arbejde - typer › Redaktør af tidsskrift › Formidling
Scientific Reports (Tidsskrift)
Almstrup, Kristian (Redaktør)
17 aug. 2020Aktivitet: Peer-review og redaktionelt arbejde - typer › Redaktør af tidsskrift › Forskning
Frontiers in Cell and Developmental Biology (Tidsskrift)
Almstrup, Kristian (Redaktør)
9 nov. 2021Aktivitet: Peer-review og redaktionelt arbejde - typer › Redaktør af tidsskrift › Forskning
ID: 33971432
Flest downloads
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286
downloads
EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Udgivet -
209
downloads
Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Udgivet -
176
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Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Udgivet