Henrik Nyhus Kløverpris

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The Kloverpris laboratory is interested in the mechanisms underlying gut immune reconstitution following injury or damage after HIV infection. To perform these studies, we have developed unique and well-characterized human tissue cohorts in areas of South Africa home to the highest HIV prevalence in the world.

Primære forskningsområder

The gut has the largest outward-facing surface area in the body. It is home to the majority of our immune and bacteria cells that exist in a complex interplay with our tissue cells. Gut homeostasis, critical for overall health, is disrupted in people living with HIV (PLWH) and plays an essential role in HIV-associated pathology not restored by long-term antiretroviral therapy (ART). Although ART significantly reduces mortality and prolongs the life of PLWH, the ageing worldwide population on ART is entering higher-risk age groups for non-communicable diseases (NCDs), including diabetes and hypertension. This represents a looming new healthcare burden, particularly in countries with limited healthcare resources.

Throughout my career, I have worked at the interface of clinical medicine and basic science and established a research programme that take advantage of the unique patient and research cohorts to generate high-impact, clinically relevant discovery science. At the Africa Health Research Institute (AHRI) in Durban, South Africa and at the University of Copenhagen, we utilise these unique and well-defined cohorts to study intestinal mucosal and lymphoid tissues in participants from areas with the highest HIV prevalence in the world. This is a great opportunity to make discoveries in PLWH that genuinely impact our understanding of health and disease in low-middle income settings. The Kloverpris lab collaborates globally and has made a series of findings on the effect of HIV infection on gut homeostasis and immune function focused on optimising immune reconstitution in PLWH.