Genomic and Phenotypic Insights for Toxigenic Clinical Vibrio cholerae O141
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Fulltext
Forlagets udgivne version, 2,52 MB, PDF-dokument
Vibrio cholerae remains a major public health threat worldwide, causing millions of cholera cases each year. Although much is known about the evolution and pathogenicity of the O1/O139 serogroups of V. cholerae, information is lacking on the molecular epidemiology of non-O1/O139 strains isolated from patients who have diarrheal illnesses. We performed whole-genome sequence analysis and in vivo infections to investigate characteristics of V. cholerae O141 isolated from sporadic diarrheal cases in 4 countries. The strains formed a distinct phylogenetic clade distinguishable from other serogroups and a unique multilocus sequence type 42, but interstrain variation suggests that O141 isolates are not clonal. These isolates encode virulence factors including cholera toxin and the toxin-coregulated pilus, as well as a type 3 secretion system. They had widely variable capacities for intestinal colonization in the infant mouse model. We propose that O141 isolates comprise a distinct clade of V. cholerae non-O1/O139, and their continued surveillance is warranted.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Emerging Infectious Diseases |
Vol/bind | 28 |
Udgave nummer | 3 |
Sider (fra-til) | 617-624 |
Antal sider | 8 |
ISSN | 1080-6040 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This study was supported by the University of Copenhagen. M.K.W. was supported by the National Institutes of Health (grant AI-042347) and the Howard Hughes Medical Institute.
Publisher Copyright:
© 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.
ID: 299206128