Vitamin D deficiency and development of complications in individuals with type 1 and type 2 diabetes: A cohort study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Aims: To investigate vitamin D deficiency as a risk marker for complications in individuals with type 1 and type 2 diabetes. Methods: A cohort study including 1448 adults with type 1 and 770 with type 2 diabetes. Individuals in the decile with lowest vitamin D level were classified as vitamin D deficient. Outcomes based on medical records and registers included mortality, major adverse cardiovascular event (MACE), heart failure, a composite kidney endpoint, albuminuria progression and sight-threatening eye disease. Risk in individuals with vitamin D deficiency was compared to the remaining using adjusted Cox proportional hazards models. Results: Vitamin D deficiency was associated with higher risk of MACE (adjusted hazard ratio (HR): 2.6; 95 % confidence interval (CI): 1.3–5.2) in type 1, but not in type 2 diabetes. Risk of heart failure was higher in individuals with vitamin D deficiency in both cohorts (HR (95%CI): 16 (4.8–50) in type 1 and 2.4 (1.1–5.5) in type 2 diabetes). Vitamin D deficiency was not associated with development of microvascular complications or mortality. Conclusions: Vitamin D deficiency was a risk marker for MACE and heart failure in type 1 and for heart failure in type 2 diabetes, but not for microvascular complications or all-cause mortality.
Originalsprog | Engelsk |
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Artikelnummer | 108611 |
Tidsskrift | Journal of Diabetes and its Complications |
Vol/bind | 37 |
Udgave nummer | 10 |
Antal sider | 6 |
ISSN | 1056-8727 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Thanks to Executive Director at Steno Diabetes Center Sjaelland Lise Tarnow for her part in initiating the StenoDot study. We thank the participants and the laboratory technicians who collected the biobank material in the StenoDot study at Steno Diabetes Center Copenhagen.
Publisher Copyright:
© 2023 Elsevier Inc.
ID: 371566978