The genetics of obesity: from discovery to biology
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
The prevalence of obesity has tripled over the past four decades, imposing an enormous burden on people’s health. Polygenic (or common) obesity and rare, severe, early-onset monogenic obesity are often polarized as distinct diseases. However, gene discovery studies for both forms of obesity show that they have shared genetic and biological underpinnings, pointing to a key role for the brain in the control of body weight. Genome-wide association studies (GWAS) with increasing sample sizes and advances in sequencing technology are the main drivers behind a recent flurry of new discoveries. However, it is the post-GWAS, cross-disciplinary collaborations, which combine new omics technologies and analytical approaches, that have started to facilitate translation of genetic loci into meaningful biology and new avenues for treatment.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Nature Reviews Genetics |
Vol/bind | 23 |
Sider (fra-til) | 120-133 |
ISSN | 1471-0056 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
R.J.F.L. is supported by funding from Novo Nordisk Foundation (NNF Laureate Award) and the US National Institutes of Health (R01DK110113; R01DK107786; R01HL142302; R01 DK124097). G.S.H.Y. is supported by the Medical Research Council (MRC Metabolic Diseases Unit (MC_UU_00014/1)). The authors thank M. Guindo Martinez for her help with creating data for Fig. 3 and Supplementary Tables 1 and 2.
Publisher Copyright:
© 2021, Springer Nature Limited.
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459824/pdf/41576_2021_Article_414.pdf
Forlagets udgivne version
ID: 281163638