Relationship between type 1 diabetes and atopic diseases in a twin population
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Relationship between type 1 diabetes and atopic diseases in a twin population. / Thomsen, S F; Duffy, D L; Kyvik, K O; Skytthe, A; Backer, V.
I: Allergy: European Journal of Allergy and Clinical Immunology, Bind 66, Nr. 5, 01.05.2011, s. 645-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Relationship between type 1 diabetes and atopic diseases in a twin population
AU - Thomsen, S F
AU - Duffy, D L
AU - Kyvik, K O
AU - Skytthe, A
AU - Backer, V
N1 - © 2010 John Wiley & Sons A/S.
PY - 2011/5/1
Y1 - 2011/5/1
N2 - AIM: To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders
AB - AIM: To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders
U2 - 10.1111/j.1398-9995.2010.02517.x
DO - 10.1111/j.1398-9995.2010.02517.x
M3 - Journal article
C2 - 21121932
VL - 66
SP - 645
EP - 647
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 5
ER -
ID: 34096916