Relationship between type 1 diabetes and atopic diseases in a twin population

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Relationship between type 1 diabetes and atopic diseases in a twin population. / Thomsen, S F; Duffy, D L; Kyvik, K O; Skytthe, A; Backer, V.

I: Allergy: European Journal of Allergy and Clinical Immunology, Bind 66, Nr. 5, 01.05.2011, s. 645-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Thomsen, SF, Duffy, DL, Kyvik, KO, Skytthe, A & Backer, V 2011, 'Relationship between type 1 diabetes and atopic diseases in a twin population', Allergy: European Journal of Allergy and Clinical Immunology, bind 66, nr. 5, s. 645-7. https://doi.org/10.1111/j.1398-9995.2010.02517.x, https://doi.org/10.1111/j.1398-9995.2010.02517.x

APA

Thomsen, S. F., Duffy, D. L., Kyvik, K. O., Skytthe, A., & Backer, V. (2011). Relationship between type 1 diabetes and atopic diseases in a twin population. Allergy: European Journal of Allergy and Clinical Immunology, 66(5), 645-7. https://doi.org/10.1111/j.1398-9995.2010.02517.x, https://doi.org/10.1111/j.1398-9995.2010.02517.x

Vancouver

Thomsen SF, Duffy DL, Kyvik KO, Skytthe A, Backer V. Relationship between type 1 diabetes and atopic diseases in a twin population. Allergy: European Journal of Allergy and Clinical Immunology. 2011 maj 1;66(5):645-7. https://doi.org/10.1111/j.1398-9995.2010.02517.x, https://doi.org/10.1111/j.1398-9995.2010.02517.x

Author

Thomsen, S F ; Duffy, D L ; Kyvik, K O ; Skytthe, A ; Backer, V. / Relationship between type 1 diabetes and atopic diseases in a twin population. I: Allergy: European Journal of Allergy and Clinical Immunology. 2011 ; Bind 66, Nr. 5. s. 645-7.

Bibtex

@article{a38fa84632594c59b85ced70ee8ab32e,
title = "Relationship between type 1 diabetes and atopic diseases in a twin population",
abstract = "AIM: To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1{\%}vs 9.9{\%}), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders",
author = "Thomsen, {S F} and Duffy, {D L} and Kyvik, {K O} and A Skytthe and V Backer",
note = "{\circledC} 2010 John Wiley & Sons A/S.",
year = "2011",
month = "5",
day = "1",
doi = "10.1111/j.1398-9995.2010.02517.x",
language = "English",
volume = "66",
pages = "645--7",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "5",

}

RIS

TY - JOUR

T1 - Relationship between type 1 diabetes and atopic diseases in a twin population

AU - Thomsen, S F

AU - Duffy, D L

AU - Kyvik, K O

AU - Skytthe, A

AU - Backer, V

N1 - © 2010 John Wiley & Sons A/S.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - AIM: To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders

AB - AIM: To study the association between type 1 diabetes and atopic diseases in a twin population.METHODS: We performed record linkage between questionnaire-defined atopic dermatitis, asthma and hay fever, and hospital discharge diagnoses of type 1 diabetes in 54,530 Danish twins, 3-71 years of age.RESULTS: The age- and sex-adjusted risk of atopic dermatitis was decreased in subjects with type 1 diabetes compared with nondiabetic subjects, (2.1%vs 9.9%), odds ratio (OR)= 0.23 (0.07-0.71), P = 0.011, whereas asthma and hay fever were not significantly associated with type 1 diabetes. Within twin pairs discordant for type 1 diabetes, the diabetic twin had a lower risk of atopic dermatitis relative to the nondiabetic co-twin. Genetic factors for atopic dermatitis and type 1 diabetes were negatively correlated (r = -0.30), P = 0.0009.CONCLUSIONS: These findings substantiate the Th1 vs Th2 cell dichotomy for type 1 diabetes and atopic dermatitis, and indicate an inverse association between genetic factors for these disorders

U2 - 10.1111/j.1398-9995.2010.02517.x

DO - 10.1111/j.1398-9995.2010.02517.x

M3 - Journal article

C2 - 21121932

VL - 66

SP - 645

EP - 647

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 5

ER -

ID: 34096916