Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts
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Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts. / Hvidtfeldt, Ulla Arthur; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J; Bellander, Tom; Brandt, Jørgen; Forastiere, Francesco; Brynedal, Boel; Hertel, Ole; Hoffmann, Barbara; Katsouyanni, Klea; Ketzel, Matthias; Leander, Karin; Magnusson, Patrik K E; Nagel, Gabriele; Pershagen, Göran; Rizzuto, Debora; Samoli, Evangelia; So, Rina; Stafoggia, Massimo; Tjønneland, Anne; Weinmayr, Gudrun; Wolf, Kathrin; Zitt, Emanuel; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.
I: Environmental Research, Bind 239, Nr. Pt 1, 117230, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts
AU - Hvidtfeldt, Ulla Arthur
AU - Chen, Jie
AU - Rodopoulou, Sophia
AU - Strak, Maciej
AU - de Hoogh, Kees
AU - Andersen, Zorana J
AU - Bellander, Tom
AU - Brandt, Jørgen
AU - Forastiere, Francesco
AU - Brynedal, Boel
AU - Hertel, Ole
AU - Hoffmann, Barbara
AU - Katsouyanni, Klea
AU - Ketzel, Matthias
AU - Leander, Karin
AU - Magnusson, Patrik K E
AU - Nagel, Gabriele
AU - Pershagen, Göran
AU - Rizzuto, Debora
AU - Samoli, Evangelia
AU - So, Rina
AU - Stafoggia, Massimo
AU - Tjønneland, Anne
AU - Weinmayr, Gudrun
AU - Wolf, Kathrin
AU - Zitt, Emanuel
AU - Brunekreef, Bert
AU - Hoek, Gerard
AU - Raaschou-Nielsen, Ole
N1 - Copyright © 2023 Elsevier Inc. All rights reserved.
PY - 2023
Y1 - 2023
N2 - BACKGROUND: Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated.METHODS: We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10-5 m-1 BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3.CONCLUSIONS: We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.
AB - BACKGROUND: Air pollution is a growing concern worldwide, with significant impacts on human health. Multiple myeloma is a type of blood cancer with increasing incidence. Studies have linked air pollution exposure to various types of cancer, including leukemia and lymphoma, however, the relationship with multiple myeloma incidence has not been extensively investigated.METHODS: We pooled four European cohorts (N = 234,803) and assessed the association between residential exposure to nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone (O3) and multiple myeloma. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level.RESULTS: During 4,415,817 person-years of follow-up (average 18.8 years), we observed 404 cases of multiple myeloma. The results of the fully adjusted linear analyses showed hazard ratios (95% confidence interval) of 0.99 (0.84, 1.16) per 10 μg/m³ NO2, 1.04 (0.82, 1.33) per 5 μg/m³ PM2.5, 0.99 (0.84, 1.18) per 0.5 10-5 m-1 BCE, and 1.11 (0.87, 1.41) per 10 μg/m³ O3.CONCLUSIONS: We did not observe an association between long-term ambient air pollution exposure and incidence of multiple myeloma.
KW - Humans
KW - Air Pollutants/toxicity
KW - Air Pollution/adverse effects
KW - Cohort Studies
KW - Environmental Exposure/adverse effects
KW - Multiple Myeloma/chemically induced
KW - Nitrogen Dioxide/toxicity
KW - Particulate Matter/analysis
U2 - 10.1016/j.envres.2023.117230
DO - 10.1016/j.envres.2023.117230
M3 - Journal article
C2 - 37806476
VL - 239
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
IS - Pt 1
M1 - 117230
ER -
ID: 374390047