Drosophila as a Model to Study the Link between Metabolism and Cancer
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Drosophila as a Model to Study the Link between Metabolism and Cancer. / Herranz, Hector; Cohen, Stephen M.
I: Journal of Developmental Biology, Bind 5, Nr. 4, 15, 12.2017.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Drosophila as a Model to Study the Link between Metabolism and Cancer
AU - Herranz, Hector
AU - Cohen, Stephen M.
PY - 2017/12
Y1 - 2017/12
N2 - Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer.
AB - Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer.
KW - Drosophila
KW - animal model
KW - metabolism
KW - cancer
KW - Warburg effect
KW - obesity
KW - type 2 diabetes
U2 - 10.3390/jdb5040015
DO - 10.3390/jdb5040015
M3 - Journal article
C2 - 29615570
VL - 5
JO - Journal of Developmental Biology
JF - Journal of Developmental Biology
IS - 4
M1 - 15
ER -
ID: 188481760