Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association (GWA) study and meta-analysis (totalling 7,946 cases and 19,036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10,260 cases and 23,500 controls). In addition to previously-reported alleles in the major histocompatibility complex (MHC) region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) (OR = 1.09, P = 1.9 x 10(-9)), and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously-described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
Originalsprog | Engelsk |
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Tidsskrift | Human Molecular Genetics |
Vol/bind | 20 |
Udgave nummer | 20 |
Sider (fra-til) | 4076-4081 |
ISSN | 0964-6906 |
DOI | |
Status | Udgivet - 26 jul. 2011 |
ID: 34045619