Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Irish Schizophrenia Genomics Consortium
  • Wellcome Trust Case Control Consortium
Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association (GWA) study and meta-analysis (totalling 7,946 cases and 19,036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10,260 cases and 23,500 controls). In addition to previously-reported alleles in the major histocompatibility complex (MHC) region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants showing genome-wide significant association: rs2312147[C], upstream of vaccinia-related kinase 2 (VRK2) (OR = 1.09, P = 1.9 x 10(-9)), and rs4309482[A], between coiled-coiled domain containing 68 (CCDC68) and TCF4, about 400 kb from the previously-described risk allele, but not accounted for by its association (OR = 1.09, P = 7.8 x 10(-9)).
TidsskriftHuman Molecular Genetics
Udgave nummer20
Sider (fra-til)4076-4081
StatusUdgivet - 26 jul. 2011

ID: 34045619