Appendiceal Neuroendocrine Neoplasms: an Update for 2023
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Appendiceal Neuroendocrine Neoplasms : an Update for 2023. / Holmager, Pernille; Langer, Seppo W.; Kjaer, Andreas; Ringholm, Lene; Garbyal, Rajendra Singh; Hansen, Carsten Palnæs; Andreassen, Mikkel; Knigge, Ulrich.
I: Current Oncology Reports, Bind 26, Nr. 2, 2024, s. 114-120.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Appendiceal Neuroendocrine Neoplasms
T2 - an Update for 2023
AU - Holmager, Pernille
AU - Langer, Seppo W.
AU - Kjaer, Andreas
AU - Ringholm, Lene
AU - Garbyal, Rajendra Singh
AU - Hansen, Carsten Palnæs
AU - Andreassen, Mikkel
AU - Knigge, Ulrich
N1 - Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2024
Y1 - 2024
N2 - Purpose of Review: To summarize the literature from the last 5 years on treatment of appendiceal neuroendocrine neoplasms (aNEN). Furthermore, to evaluate the prognostic significance of lymph node metastases, indications for adjuvant treatment, and challenges of the current follow-up regimen. Recent Findings: Simple appendectomy is sufficient in tumors < 1 cm while extended surgery is indicated in tumors > 2 cm. In a multicenter study of aNENs measuring 1–2 cm, extended surgery offered no significant prognostic advantage and is now limited to incomplete tumor resection or high-grade G2 or G3 aNEN. Follow-up remains debatable, as the use of imaging and biomarkers lacks validation. Summary: While surgical procedure is well established in aNEN tumors < 1 cm and > 2 cm, the need for extended surgery in aNEN tumors 1–2 cm is questionable. Future studies should address the prognostic impact of lymph node metastases and the optimal design and duration of follow-up.
AB - Purpose of Review: To summarize the literature from the last 5 years on treatment of appendiceal neuroendocrine neoplasms (aNEN). Furthermore, to evaluate the prognostic significance of lymph node metastases, indications for adjuvant treatment, and challenges of the current follow-up regimen. Recent Findings: Simple appendectomy is sufficient in tumors < 1 cm while extended surgery is indicated in tumors > 2 cm. In a multicenter study of aNENs measuring 1–2 cm, extended surgery offered no significant prognostic advantage and is now limited to incomplete tumor resection or high-grade G2 or G3 aNEN. Follow-up remains debatable, as the use of imaging and biomarkers lacks validation. Summary: While surgical procedure is well established in aNEN tumors < 1 cm and > 2 cm, the need for extended surgery in aNEN tumors 1–2 cm is questionable. Future studies should address the prognostic impact of lymph node metastases and the optimal design and duration of follow-up.
KW - Appendiceal
KW - Follow-up
KW - Neuroendocrine neoplasm
KW - Treatment
U2 - 10.1007/s11912-023-01484-4
DO - 10.1007/s11912-023-01484-4
M3 - Review
C2 - 38168835
AN - SCOPUS:85181192700
VL - 26
SP - 114
EP - 120
JO - Current Oncology Reports
JF - Current Oncology Reports
SN - 1523-3790
IS - 2
ER -
ID: 379658039