Z-score transformation of T-wave morphology values to a standardized scale
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Z-score transformation of T-wave morphology values to a standardized scale. / Graff, C.; Nielsen, J.; Kanters, J. K.; Matz, J.; Schmidt, S. E.; Toft, E.; Struijk, J. J.
Computing in Cardiology 2011, CinC 2011. Vol. 38 2011. p. 737-740 6164671.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review
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TY - GEN
T1 - Z-score transformation of T-wave morphology values to a standardized scale
AU - Graff, C.
AU - Nielsen, J.
AU - Kanters, J. K.
AU - Matz, J.
AU - Schmidt, S. E.
AU - Toft, E.
AU - Struijk, J. J.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.
AB - Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.
UR - http://www.scopus.com/inward/record.url?scp=84859990662&partnerID=8YFLogxK
M3 - Article in proceedings
AN - SCOPUS:84859990662
SN - 9781457706127
VL - 38
SP - 737
EP - 740
BT - Computing in Cardiology 2011, CinC 2011
T2 - Computing in Cardiology 2011, CinC 2011
Y2 - 18 September 2011 through 21 September 2011
ER -
ID: 204298799