Working memory heterogeneity from age 7 to 11 in children at familial high risk of schizophrenia or bipolar disorder– The Danish High Risk and Resilience Study
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Working memory heterogeneity from age 7 to 11 in children at familial high risk of schizophrenia or bipolar disorder– The Danish High Risk and Resilience Study. / Andreassen, Anna Krogh; Lambek, Rikke; Hemager, Nicoline; Knudsen, Christina Bruun; Veddum, Lotte; Carlsen, Anders Helles; Bundgaard, Anette Faurskov; Søndergaard, Anne; Brandt, Julie Marie; Gregersen, Maja; Krantz, Mette Falkenberg; Burton, Birgitte Klee; Jepsen, Jens Richardt Møllegaard; Thorup, Anne Amalie Elgaard; Nordentoft, Merete; Mors, Ole; Bliksted, Vibeke Fuglsang; Greve, Aja.
In: Journal of Affective Disorders, Vol. 332, 2023, p. 318-326.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Working memory heterogeneity from age 7 to 11 in children at familial high risk of schizophrenia or bipolar disorder– The Danish High Risk and Resilience Study
AU - Andreassen, Anna Krogh
AU - Lambek, Rikke
AU - Hemager, Nicoline
AU - Knudsen, Christina Bruun
AU - Veddum, Lotte
AU - Carlsen, Anders Helles
AU - Bundgaard, Anette Faurskov
AU - Søndergaard, Anne
AU - Brandt, Julie Marie
AU - Gregersen, Maja
AU - Krantz, Mette Falkenberg
AU - Burton, Birgitte Klee
AU - Jepsen, Jens Richardt Møllegaard
AU - Thorup, Anne Amalie Elgaard
AU - Nordentoft, Merete
AU - Mors, Ole
AU - Bliksted, Vibeke Fuglsang
AU - Greve, Aja
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Background: Despite the genetic overlap between bipolar disorder and schizophrenia, working memory impairments are mainly found in children of parents with schizophrenia. However, working memory impairments are characterized by substantial heterogeneity, and it is unknown how this heterogeneity develops over time. We used a data-driven approach to assess working memory heterogeneity and longitudinal stability in children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP). Methods: Based on the performances on four working memory tasks by 319 children (FHR-SZ, N = 202, FHR-BP, N = 118) measured at age 7 and 11, latent profile transition analysis was used to test for the presence of subgroups, and the stability of subgroup membership over time. Population-based controls (VIA 7, N = 200, VIA 11, N = 173) were included as a reference group. The working memory subgroups were compared based on caregiver- and teacher ratings of everyday working memory function, and dimensional psychopathology. Results: A model with three subgroups characterized by different levels of working memory function (an impaired subgroup, a mixed subgroup, and an above average subgroup) best fitted the data. The impaired subgroup had the highest ratings of everyday working memory impairments and psychopathology. Overall, 98 % (N = 314) stayed in the same subgroup from age 7 to 11. Conclusion: Persistent working memory impairments are present in a subset of children at FHR-SZ and FHR-BP throughout middle childhood. Attention should be given to these children, as working memory impairments influence daily life, and may serve as a vulnerability marker of transition to severe mental illness.
AB - Background: Despite the genetic overlap between bipolar disorder and schizophrenia, working memory impairments are mainly found in children of parents with schizophrenia. However, working memory impairments are characterized by substantial heterogeneity, and it is unknown how this heterogeneity develops over time. We used a data-driven approach to assess working memory heterogeneity and longitudinal stability in children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP). Methods: Based on the performances on four working memory tasks by 319 children (FHR-SZ, N = 202, FHR-BP, N = 118) measured at age 7 and 11, latent profile transition analysis was used to test for the presence of subgroups, and the stability of subgroup membership over time. Population-based controls (VIA 7, N = 200, VIA 11, N = 173) were included as a reference group. The working memory subgroups were compared based on caregiver- and teacher ratings of everyday working memory function, and dimensional psychopathology. Results: A model with three subgroups characterized by different levels of working memory function (an impaired subgroup, a mixed subgroup, and an above average subgroup) best fitted the data. The impaired subgroup had the highest ratings of everyday working memory impairments and psychopathology. Overall, 98 % (N = 314) stayed in the same subgroup from age 7 to 11. Conclusion: Persistent working memory impairments are present in a subset of children at FHR-SZ and FHR-BP throughout middle childhood. Attention should be given to these children, as working memory impairments influence daily life, and may serve as a vulnerability marker of transition to severe mental illness.
KW - Bipolar disorder
KW - Familial high risk
KW - Heterogeneity
KW - Schizophrenia
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=85152564937&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2023.04.011
DO - 10.1016/j.jad.2023.04.011
M3 - Journal article
C2 - 37059192
AN - SCOPUS:85152564937
VL - 332
SP - 318
EP - 326
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 370730651