Women produce fewer but triglyceride-richer very low-density lipoproteins than men
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Women produce fewer but triglyceride-richer very low-density lipoproteins than men. / Magkos, Faidon; Patterson, Bruce W; Mohammed, B Selma; Klein, Samuel; Mittendorfer, Bettina.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 4, 2007, p. 1311-1318.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Women produce fewer but triglyceride-richer very low-density lipoproteins than men
AU - Magkos, Faidon
AU - Patterson, Bruce W
AU - Mohammed, B Selma
AU - Klein, Samuel
AU - Mittendorfer, Bettina
N1 - (Ekstern)
PY - 2007
Y1 - 2007
N2 - Context: Very low-density lipoproteins (VLDL) are a major risk factor for cardiovascular disease. The concentrations of VLDL particles and VLDL-triglyceride (TG) in plasma are lower in women than men, but the mechanisms responsible for these differences are unclear.Objective: The objective of the study was to investigate the effects of sex on VLDL-TG and VLDL-apolipoprotein B-100 (apoB-100) metabolism.Experimental design and main outcome measures: We measured basal VLDL-TG and VLDL-apoB-100 kinetics by using stable isotope labeled tracers.Setting / paticipants: Twenty-six healthy, lean subjects (13 men, aged 29+/-5 yr; 13 women, aged 28+/-6 yr) were studied in the General Clinical Research Center at Washington University School of Medicine.Results: VLDL-TG and VLDL-apoB-100 concentrations were less in women than men (P<0.05). The secretion rate of VLDL-TG was approximately 70% greater (P<0.05), whereas the secretion rate of VLDL-apoB-100 (i.e. VLDL particles) was approximately 20% less (P<0.05) in women than men. The molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates was therefore more than double (P<0.05) in women than men. VLDL-TG plasma clearance rate was approximately 70% greater in women than men (P<0.05), whereas VLDL-apoB-100 plasma clearance rate was not different between sexes. However, VLDL-TG and VLDL-apoB-100 mean residence times in plasma were both shorter (by 45 and 25%, respectively; P<0.05) in women than men.Conclusions: Increased VLDL-TG plasma clearance is responsible for lower VLDL-TG concentration, whereas decreased VLDL-apoB-100 secretion rate, combined with shorter VLDL-apoB-100 residence time in plasma, is responsible for lower VLDL-apoB-100 concentration in women than men. The greater molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates suggests that the liver in women secretes fewer but TG-richer VLDL particles than the liver in men.
AB - Context: Very low-density lipoproteins (VLDL) are a major risk factor for cardiovascular disease. The concentrations of VLDL particles and VLDL-triglyceride (TG) in plasma are lower in women than men, but the mechanisms responsible for these differences are unclear.Objective: The objective of the study was to investigate the effects of sex on VLDL-TG and VLDL-apolipoprotein B-100 (apoB-100) metabolism.Experimental design and main outcome measures: We measured basal VLDL-TG and VLDL-apoB-100 kinetics by using stable isotope labeled tracers.Setting / paticipants: Twenty-six healthy, lean subjects (13 men, aged 29+/-5 yr; 13 women, aged 28+/-6 yr) were studied in the General Clinical Research Center at Washington University School of Medicine.Results: VLDL-TG and VLDL-apoB-100 concentrations were less in women than men (P<0.05). The secretion rate of VLDL-TG was approximately 70% greater (P<0.05), whereas the secretion rate of VLDL-apoB-100 (i.e. VLDL particles) was approximately 20% less (P<0.05) in women than men. The molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates was therefore more than double (P<0.05) in women than men. VLDL-TG plasma clearance rate was approximately 70% greater in women than men (P<0.05), whereas VLDL-apoB-100 plasma clearance rate was not different between sexes. However, VLDL-TG and VLDL-apoB-100 mean residence times in plasma were both shorter (by 45 and 25%, respectively; P<0.05) in women than men.Conclusions: Increased VLDL-TG plasma clearance is responsible for lower VLDL-TG concentration, whereas decreased VLDL-apoB-100 secretion rate, combined with shorter VLDL-apoB-100 residence time in plasma, is responsible for lower VLDL-apoB-100 concentration in women than men. The greater molar ratio of VLDL-TG and VLDL-apoB-100 secretion rates suggests that the liver in women secretes fewer but TG-richer VLDL particles than the liver in men.
KW - Adipose Tissue/anatomy & histology
KW - Adult
KW - Apolipoprotein B-100/blood
KW - Body Height
KW - Body Mass Index
KW - Body Weight
KW - Fatty Acids, Nonesterified/blood
KW - Female
KW - Hormones/blood
KW - Humans
KW - Insulin/blood
KW - Lipoproteins, LDL/blood
KW - Male
KW - Sex Characteristics
KW - Triglycerides/blood
U2 - 10.1210/jc.2006-2215
DO - 10.1210/jc.2006-2215
M3 - Journal article
C2 - 17264179
VL - 92
SP - 1311
EP - 1318
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 4
ER -
ID: 297154222