Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease
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Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease. / Nielsen, Yousef W; Eiberg, Jonas P; Logager, Vibeke B; Schroeder, Torben V; Just, Sven; Thomsen, Henrik S; Nielsen, Yousef W; Eiberg, Jonas P; Logager, Vibeke B; Schroeder, Torben V; Just, Sven; Thomsen, Henrik S.
In: Cardiovascular and Interventional Radiology, Vol. 32, No. 5, 01.09.2009, p. 877-86.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Whole-body magnetic resonance angiography at 3 tesla using a hybrid protocol in patients with peripheral arterial disease
AU - Nielsen, Yousef W
AU - Eiberg, Jonas P
AU - Logager, Vibeke B
AU - Schroeder, Torben V
AU - Just, Sven
AU - Thomsen, Henrik S
AU - Nielsen, Yousef W
AU - Eiberg, Jonas P
AU - Logager, Vibeke B
AU - Schroeder, Torben V
AU - Just, Sven
AU - Thomsen, Henrik S
N1 - Keywords: Adult; Aged; Aged, 80 and over; Angiography, Digital Subtraction; Contrast Media; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Angiography; Male; Meglumine; Middle Aged; Organometallic Compounds; Peripheral Vascular Diseases; Sensitivity and Specificity; Statistics, Nonparametric; Whole Body Imaging
PY - 2009/9/1
Y1 - 2009/9/1
N2 - The purpose of this study was to determine the diagnostic performance of 3T whole-body magnetic resonance angiography (WB-MRA) using a hybrid protocol in comparison with a standard protocol in patients with peripheral arterial disease (PAD). In 26 consecutive patients with PAD two different protocols were used for WB-MRA: a standard sequential protocol (n = 13) and a hybrid protocol (n = 13). WB-MRA was performed using a gradient echo sequence, body coil for signal reception, and gadoterate meglumine as contrast agent (0.3 mmol/kg body weight). Two blinded observers evaluated all WB-MRA examinations with regard to presence of stenoses, as well as diagnostic quality and degree of venous contamination in each of the four stations used in WB-MRA. Digital subtraction angiography served as the method of reference. Sensitivity for detecting significant arterial disease (luminal narrowing > or = 50%) using standard-protocol WB-MRA for the two observers was 0.63 (95%CI: 0.51-0.73) and 0.66 (0.58-0.78). Specificities were 0.94 (0.91-0.97) and 0.96 (0.92-0.98), respectively. In the hybrid protocol WB-MRA sensitivities were 0.75 (0.64-0.84) and 0.70 (0.58-0.8), respectively. Specificities were 0.93 (0.88-0.96) and 0.95 (0.91-0.97). Interobserver agreement was good using both the standard and the hybrid protocol, with kappa = 0.62 (0.44-0.67) and kappa = 0.70 (0.59-0.79), respectively. WB-MRA quality scores were significantly higher in the lower leg using the hybrid protocol compared to standard protocol (p = 0.003 and p = 0.03, observers 1 and 2). Distal venous contamination scores were significantly lower with the hybrid protocol (p = 0.02 and p = 0.01, observers 1 and 2). In conclusion, hybrid-protocol WB-MRA shows a better diagnostic performance than standard protocol WB-MRA at 3 T in patients with PAD.
AB - The purpose of this study was to determine the diagnostic performance of 3T whole-body magnetic resonance angiography (WB-MRA) using a hybrid protocol in comparison with a standard protocol in patients with peripheral arterial disease (PAD). In 26 consecutive patients with PAD two different protocols were used for WB-MRA: a standard sequential protocol (n = 13) and a hybrid protocol (n = 13). WB-MRA was performed using a gradient echo sequence, body coil for signal reception, and gadoterate meglumine as contrast agent (0.3 mmol/kg body weight). Two blinded observers evaluated all WB-MRA examinations with regard to presence of stenoses, as well as diagnostic quality and degree of venous contamination in each of the four stations used in WB-MRA. Digital subtraction angiography served as the method of reference. Sensitivity for detecting significant arterial disease (luminal narrowing > or = 50%) using standard-protocol WB-MRA for the two observers was 0.63 (95%CI: 0.51-0.73) and 0.66 (0.58-0.78). Specificities were 0.94 (0.91-0.97) and 0.96 (0.92-0.98), respectively. In the hybrid protocol WB-MRA sensitivities were 0.75 (0.64-0.84) and 0.70 (0.58-0.8), respectively. Specificities were 0.93 (0.88-0.96) and 0.95 (0.91-0.97). Interobserver agreement was good using both the standard and the hybrid protocol, with kappa = 0.62 (0.44-0.67) and kappa = 0.70 (0.59-0.79), respectively. WB-MRA quality scores were significantly higher in the lower leg using the hybrid protocol compared to standard protocol (p = 0.003 and p = 0.03, observers 1 and 2). Distal venous contamination scores were significantly lower with the hybrid protocol (p = 0.02 and p = 0.01, observers 1 and 2). In conclusion, hybrid-protocol WB-MRA shows a better diagnostic performance than standard protocol WB-MRA at 3 T in patients with PAD.
U2 - 10.1007/s00270-009-9549-z
DO - 10.1007/s00270-009-9549-z
M3 - Journal article
C2 - 19296155
VL - 32
SP - 877
EP - 886
JO - CardioVascular and Interventional Radiology
JF - CardioVascular and Interventional Radiology
SN - 0174-1551
IS - 5
ER -
ID: 16915060