Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish
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Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish. / Koltowska, Katarzyna; Lagendijk, Anne Karine; Pichol-Thievend, Cathy; Fischer, Johanna C; Francois, Mathias; Ober, Elke A; Yap, Alpha S; Hogan, Benjamin M.
In: Cell Reports, Vol. 13, No. 9, 01.12.2015, p. 1828-41.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish
AU - Koltowska, Katarzyna
AU - Lagendijk, Anne Karine
AU - Pichol-Thievend, Cathy
AU - Fischer, Johanna C
AU - Francois, Mathias
AU - Ober, Elke A
AU - Yap, Alpha S
AU - Hogan, Benjamin M
N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood. We report the visualization of zebrafish lymphatic precursor cell dynamics during fate restriction. In the cardinal vein, cellular commitment is linked with the division of bipotential Prox1-positive precursor cells, which occurs immediately prior to sprouting angiogenesis. Following precursor division, identities are established asymmetrically in daughter cells; one daughter cell becomes lymphatic and progressively upregulates Prox1, and the other downregulates Prox1 and remains in the vein. Vegfc drives cell division and Prox1 expression in lymphatic daughter cells, coupling signaling dynamics with daughter cell fate restriction and precursor division.
AB - Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood. We report the visualization of zebrafish lymphatic precursor cell dynamics during fate restriction. In the cardinal vein, cellular commitment is linked with the division of bipotential Prox1-positive precursor cells, which occurs immediately prior to sprouting angiogenesis. Following precursor division, identities are established asymmetrically in daughter cells; one daughter cell becomes lymphatic and progressively upregulates Prox1, and the other downregulates Prox1 and remains in the vein. Vegfc drives cell division and Prox1 expression in lymphatic daughter cells, coupling signaling dynamics with daughter cell fate restriction and precursor division.
U2 - 10.1016/j.celrep.2015.10.055
DO - 10.1016/j.celrep.2015.10.055
M3 - Journal article
C2 - 26655899
VL - 13
SP - 1828
EP - 1841
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 9
ER -
ID: 160406446